Synthesis, Nematicidal Activity, and Molecular Docking of Some New Pyrazole-5-carboxamide Derivatives with Flexible Chain

A series of new pyrazole-5-carboxamide derivatives was synthesized containing flexible chain moiety. The synthetic route involved four-step approach starting from ethyl 3-ethyl-1-methyl-1 H-pyrazole-5-carboxylate (1). The primarily nematicidal bioassay results have shown that some of them exhibited moderate activity against Meloidogyne incognita at 10 mg/L. In addition, the molecular docking simulation results indicated that compound 5r interacts with succinate dehydrogenase (SDH) through it-cation, it- it , and hydrogen bond interaction, which may provide useful information to further design novel nematicides.