Visible-light-induced trifluoromethylation/cyclization of unactivated alkenes: Synthesis of CF3-substituted fused tricyclic indoles

被引：3

作者：

Jiao, Jialong ^{[1
]}

Geng, Yang ^{[2
]}

Zhang, Shanshan ^{[1
]}

Zou, Dapeng ^{[1
]}

Wu, Yangjie ^{[1
]}

Wu, Yusheng ^{[1
,3
,4
]}

机构：

[1] Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China

[2] Zhengzhou Railway Vocat & Tech Coll, Dept Pharm, Zhengzhou 451460, Peoples R China

[3] TYK Med Inc, Huzhou 313000, Peoples R China

[4] Tetranov Int Inc, 100 Jersey Ave,Suite A340, New Brunswick, NJ 08901 USA

来源：

TETRAHEDRON LETTERS | 2024年 / 147卷

基金：

中国国家自然科学基金;

关键词：

Visible-light-irradiation; Trifluoromethylation; Cyclization; Tricyclic indole; RADICAL CASCADE CYCLIZATION; FLUORINE; DESIGN;

D O I：

10.1016/j.tetlet.2024.155218

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A visible-light-induced radical trifluoromethylation/cyclization of unactivated alkenes for the construction of trifluoromethylated tricyclic indoles with readily accessible trifluoromethyl thianthrenium triflate has been reported. A variety of CF3-containing tricyclic indole derivatives were synthesized at room temperature without the addition of photocatalysts or additives. Mechanistic investigations indicate that the reaction probably undergo a radical pathway.

引用

页数：5

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