Exploring the causal relationship between psoriasis and osteoarthritis through a 2-sample Mendelian randomization study

被引:0
作者
Yao, Haoyu [1 ]
Lu, Peizhi [1 ]
Li, Ya [1 ]
Yang, Shuo [1 ]
Wang, Shijie [1 ]
Fan, Zihao [1 ]
Ning, Rende [1 ]
机构
[1] Anhui Med Univ, Peoples Hosp Hefei 1, Affiliated Hosp 3, Dept Orthoped, Hefei 230061, Anhui, Peoples R China
关键词
Mendelian randomization; osteoarthritis; psoriasis; psoriatic arthritis; EPIDEMIOLOGY;
D O I
10.1097/MD.0000000000039303
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Previous research has demonstrated a robust association between osteoarthritis (OA) and psoriasis. Notably, a significant proportion of psoriasis patients exhibit symptoms of arthritis, particularly psoriatic arthritis. However, a definitive causal relationship between psoriasis, psoriatic arthritis and OA remains to be established. This study aimed to elucidate the causal relationship between psoriasis, psoriatic arthritis, and osteoarthritis using a 2-sample Mendelian randomization approach. The causal relationship between psoriasis, psoriatic arthritis and OA was rigorously investigated using a 2-sample Mendelian Randomization (MR) approach. Instrumental variables pertinent to psoriasis, psoriatic arthritis and 4 distinct types of OA (knee osteoarthritis (KOA), hand osteoarthritis (HOA), total knee replacement (TKR), and total hip replacement (THR)) were sourced from extensive, published genome-wide association studies (GWAS). To estimate the causal effects, methodologies such as inverse variance weighting (IVW), MR-Egger, and weighted median estimation (WM) were employed. Mendelian Randomization analysis suggested a potential causal effect of psoriasis on osteoarthritis (OA). For hand OA (HOA), the P value was .381 (OR = 0.28); for knee OA (KOA), the P value was .725 (OR = 1.46); for TKR, the P value was .488 (OR = 0.274); and for THR, the P value was .454 (OR = 0.216). Furthermore, we explored the causality of psoriatic arthritis on OA. For HOA, the P value was .478 (OR = 0.0095); for KOA, the P value was .835 (OR = 0.345); for THR, the P value was .807 (OR = 0.120); and for TKR, the P value was .860 (OR = 0.190). Our findings indicate that there is no evidence of a causal connection between psoriasis or psoriatic arthritis and OA, suggesting that while psoriasis may contribute to arthritis, it does not influence OA development.
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页数:9
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