Lactic Acid Bacteria-Gut-Microbiota-Mediated Intervention towards Inflammatory Bowel Disease

被引：2

作者：

Li, Diantong ^{[1
,2
]}

Liu, Zhenjiang ^{[1
,3
]}

Fan, Xueni ^{[1
,2
]}

Zhao, Tingting ^{[1
,2
]}

Wen, Dongxu ^{[1
]}

Huang, Xiaodan ^{[1
,2
]}

Li, Bin ^{[1
]}

机构：

[1] Xizang Acad Agr & Anim Husb Sci, Inst Anim Husb & Vet, Key Lab Anim Genet & Breeding Tibetan Plateau, Minist Agr & Rural Affairs, Lhasa 850000, Peoples R China

[2] Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Peoples R China

[3] Jilin Univ, Sch Life Sci, Natl Engn Lab AIDS Vaccine, Changchun 130012, Peoples R China

来源：

MICROORGANISMS | 2024年 / 12卷 / 09期

关键词：

inflammatory bowel disease; ulcerative colitis; Crohn's disease; lactic acid bacteria; INTESTINAL EPITHELIAL-CELLS; AMBIENT AIR-POLLUTION; CHAIN FATTY-ACIDS; ULCERATIVE-COLITIS; PROBIOTIC VSLNUMBER-3; EMERGING ROLE; NOD2; AMOXICILLIN; THERAPY; MECHANISMS;

D O I：

10.3390/microorganisms12091864

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), arises from intricate interactions involving genetics, environment, and pharmaceuticals with an ambiguous pathogenic mechanism. Recently, there has been an increasing utilization of lactic acid bacteria (LAB) in managing IBD, attributed to their ability to enhance intestinal barrier function, mitigate inflammatory responses, and modulate gut microbiota. This review initiates by elucidating the pathogenesis of IBD and its determinants, followed by an exploration of the mechanisms underlying LAB therapy in UC and CD. Special attention is directed towards their influence on intestinal barrier function and homeostasis regulated by gut microbiota. Furthermore, the review investigates the complex interplay among pivotal gut microbiota, metabolites, and pathways associated with inflammation. Moreover, it underscores the limitations of LAB in treating IBD, particularly in light of their varying roles in UC and CD. This comprehensive analysis endeavors to offer insights for the optimized application of LAB in IBD therapy.

引用

页数：15