The Role of the Gut and Airway Microbiota in Chronic Rhinosinusitis with Nasal Polyps: A Systematic Review

被引:1
|
作者
Gomez-Garcia, Manuel [1 ,2 ]
Moreno-Jimenez, Emma [1 ,3 ]
Morgado, Natalia [1 ,4 ]
Garcia-Sanchez, Asuncion [1 ,4 ,5 ]
Gil-Melcon, Maria [1 ,6 ]
Perez-Pazos, Jacqueline [1 ,2 ,7 ]
Estravis, Miguel [1 ,5 ]
Isidoro-Garcia, Maria [1 ,2 ,5 ,8 ]
Davila, Ignacio [1 ,4 ,5 ,9 ]
Sanz, Catalina [1 ,3 ,5 ]
机构
[1] Inst Biomed Res Salamanca IBSAL, Salamanca 37007, Spain
[2] Univ Hosp Salamanca, Clin Biochem Dept, Pharmacogenet & Precis Med Unit, Salamanca 37007, Spain
[3] Univ Salamanca, Dept Microbiol & Genet, Salamanca 37007, Spain
[4] Univ Salamanca, Biomed & Diagnost Sci Dept, Salamanca 37007, Spain
[5] Carlos III Hlth Inst, Results Oriented Cooperat Res Networks Hlth Red En, Madrid 28220, Spain
[6] Univ Hosp Salamanca, Otorhinolaryngol & Head & Neck Surg Dept, Salamanca 37007, Spain
[7] Carlos III Hlth Inst, Ctr Networked Biomed Res Cardiovasc Dis CIBERCV, Madrid 28220, Spain
[8] Univ Salamanca, Med Dept, Salamanca 37007, Spain
[9] Univ Hosp Salamanca, Dept Allergy, Salamanca 37007, Spain
关键词
chronic rhinosinusitis with nasal polyps; human microbiota; respiratory diseases; immune system; functional modulation of the microbiota; BACTERIOLOGICAL ANALYSIS; RESPIRATORY-TRACT; PARANASAL SINUSES; CHRONIC SINUSITIS; MAXILLARY SINUS; MIDDLE MEATUS; ASTHMA; RECURRENCE; THERAPIES; EXPOSURE;
D O I
10.3390/ijms25158223
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In recent years, there has been growing interest in understanding the potential role of microbiota dysbiosis or alterations in the composition and function of human microbiota in the development of chronic rhinosinusitis with nasal polyposis (CRSwNP). This systematic review evaluated the literature on CRSwNP and host microbiota for the last ten years, including mainly nasal bacteria, viruses, and fungi, following the PRISMA guidelines and using the major scientific publication databases. Seventy original papers, mainly from Asia and Europe, met the inclusion criteria, providing a comprehensive overview of the microbiota composition in CRSwNP patients and its implications for inflammatory processes in nasal polyps. This review also explores the potential impact of microbiota-modulating therapies for the CRSwNP treatment. Despite variability in study populations and methodologies, findings suggest that fluctuations in specific taxa abundance and reduced bacterial diversity can be accepted as critical factors influencing the onset or severity of CRSwNP. These microbiota alterations appear to be implicated in triggering cell-mediated immune responses, cytokine cascade changes, and defects in the epithelial barrier. Although further human studies are required, microbiota-modulating strategies could become integral to future combined CRSwNP treatments, complementing current therapies that mainly target inflammatory mediators and potentially improving patient outcomes.
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页数:54
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