Periodontal ligament and bone marrow derived stem cells in periodontal regeneration - A systematic review

Background: Periodontal therapy aims to slow the progression of periodontal disease and encourage regeneration. Clinically, a number of periodontal therapies are used to treat periodontitis. Stem cell-based tissue regeneration is currently thought to be a promising therapeutic approach for periodontal tissue regeneration. Objective: The systemic review's objective is to assess and compare the efficacy of periodontal ligament derived stem cells and bone marrow-derived stem cells in periodontal regeneration. Methods: The Preferred Reporting Items for Systematic Review recommendations will be followed while conducting a systematic review. The efficiency of bone marrowderived stem cells (BMSCs) and stem cells produced from periodontal ligaments (PDLSCs) in regenerating periodontal tissue will be assessed. From 2013 to 2023, search engines will be utilized to identify appropriate information from databases like PubMed, Web of Science, and Scopus in order to locate research studies on PDLSCs and BMSCs in periodontal regeneration. The newly created periodontal ligament (NPDL), newly formed cementum (NC), and newly produced alveolar bone (NB) will be the main outcomes. Results: The research evaluating bone marrow-derived stem cells-based therapies and periodontal ligamentderived stem cell-based therapies for the regeneration of periodontal tissue will be identified, and their efficacy in terms of histologic markers will be compared. Conclusion: The most popular and efficient stem cell types for regenerating periodontal tissue are those produced from bone marrow and periodontal ligaments. The research will aid in the eventual clinical application of stem cell research.