The Biological Mechanisms and Clinical Roles of RNA-Binding Proteins in Cardiovascular Diseases

被引：3
作者：
Lin, Lizhu [1 ]
Chu, Jiemei [2 ]
An, Sanqi [2 ]
Liu, Xinli [2 ]
Tan, Runxian [3 ]
机构：
[1] Guangxi Med Univ, Peoples Hosp Qinzhou 1, Affiliated Hosp 10, Dept Anaesthesiol, Qinzhou 535000, Peoples R China
[2] Guangxi Med Univ, Life Sci Inst, Nanning 530021, Peoples R China
[3] Guangxi Med Univ, Peoples Hosp Qinzhou 1, Affiliated Hosp 10, Dept Lab Med, Qinzhou 535000, Peoples R China
来源：
BIOMOLECULES | 2024年 / 14卷 / 09期
关键词：
RNA-binding proteins (RBPs); cardiovascular diseases (CVDs); myocardial injury; RNA alternative splicing; therapeutic targets; biomarkers; MESSENGER-RNA; NETWORKS; RBFOX2; ATHEROSCLEROSIS; CARDIOTOXICITY; ACTIVATION; EXPRESSION; PROTEOME; QUAKING;
D O I：
10.3390/biom14091056
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
RNA-binding proteins (RBPs) have pivotal roles in cardiovascular biology, influencing various molecular mechanisms underlying cardiovascular diseases (CVDs). This review explores the significant roles of RBPs, focusing on their regulation of RNA alternative splicing, polyadenylation, and RNA editing, and their impact on CVD pathogenesis. For instance, RBPs are crucial in myocardial injury, contributing to disease progression and repair mechanisms. This review systematically analyzes the roles of RBPs in myocardial injury, arrhythmias, myocardial infarction, and heart failure, revealing intricate interactions that influence disease outcomes. Furthermore, the potential of RBPs as therapeutic targets for cardiovascular dysfunction is explored, highlighting the advances in drug development and clinical research. This review also discusses the emerging role of RBPs as biomarkers for cardiovascular diseases, offering insights into their diagnostic and prognostic potential. Despite significant progress, current research faces several limitations, which are critically examined. Finally, this review identifies the major challenges and outlines future research directions to advance the understanding and application of RBPs in cardiovascular medicine.
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页数：24
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