Role of medial prefrontal cortex voltage-dependent potassium 4.3 channels in nicotine-induced enhancement of object recognition memory in male mice

被引:3
作者
Esaki, Hirohito [1 ]
Izumi, Shoma [1 ]
Nishikawa, Keisuke [1 ]
Nagayasu, Kazuki [2 ]
Kaneko, Shuji [2 ]
Nishitani, Naoya [1 ]
Deyama, Satoshi [1 ]
Kaneda, Katsuyuki [1 ]
机构
[1] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Lab Mol Pharmacol, Kanazawa 9201192, Japan
[2] Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Mol Pharmacol, 46-29 Yoshida Shimoadachi cho,Sakyo ku, Kyoto 6068501, Japan
基金
日本科学技术振兴机构;
关键词
nicotinic acetylcholine receptors (nAChRs); Voltage-dependent potassium (Kv) channels; Medial prefrontal cortex (mPFC); nicotine; Novel object recognition (NOR) test; DENDRITIC K+ CHANNELS; SHORT-TERM-MEMORY; PYRAMIDAL NEURONS; SEX-DIFFERENCES; ACETYLCHOLINE-RECEPTORS; INTRINSIC EXCITABILITY; SYNAPTIC-INTERACTIONS; KV4.3; CHANNELS; MODULATION; ALPHA-7;
D O I
10.1016/j.ejphar.2024.176790
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Nicotine has been shown to enhance object recognition memory in the novel object recognition (NOR) test by activating excitatory neurons in the medial prefrontal cortex (mPFC). However, the exact neuronal mechanisms underlying the nicotine-induced activation of mPFC neurons and the resultant memory enhancement remain poorly understood. To address this issue, we performed brain-slice electrophysiology and the NOR test in male C57BL/6J mice. Whole-cell patch-clamp recordings from layer V pyramidal neurons in the mPFC revealed that nicotine augments the summation of evoked excitatory postsynaptic potentials (eEPSPs) and that this effect was suppressed by N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea (NS5806), a voltage-dependent potassium (Kv) 4.3 channel activator. In line with these findings, intra-mPFC infusion of NS5806 suppressed systemically administered nicotine-induced memory enhancement in the NOR test. Additionally, miRNA-mediated knockdown of Kv4.3 channels in mPFC pyramidal neurons enhanced object recognition memory. Furthermore, inhibition of A-type Kv channels by intra-mPFC infusion of 4-aminopyridine was found to enhance object recognition memory, while this effect was abrogated by prior intra-mPFC NS5806 infusion. These results suggest that nicotine augments the summation of eEPSPs via the inhibition of Kv4.3 channels in mPFC layer V pyramidal neurons, resulting in the enhancement of object recognition memory.
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页数:10
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