We are MedChem: The Frontiers in Medicinal Chemistry 2024

被引:0
作者
Schiedel, Matthias [1 ]
Barbie, Philipp [2 ]
Pape, Felix [3 ]
Pinto, Marta [4 ]
Lopez, Andrea Unzue [5 ]
Mendez, Maria [6 ]
Hessler, Gerhard [6 ]
Merk, Daniel [7 ]
Gehringer, Matthias [8 ,9 ]
Lamers, Christina [10 ]
机构
[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, Beethovenstr 55, D-38106 Braunschweig, Germany
[2] Bayer AG, Pharmaceut Lab 4, R&D, Bldg S106,231, D-13342 Berlin, Germany
[3] NUVISAN GmbH, Muellerstr 178, D-13353 Berlin, Germany
[4] AbbVie Deutschland GmbH & Co KG, Computat Drug Discovery, Knollstr, D-67061 Ludwigshafen, Germany
[5] Merck Healthcare KGaA, Frankfurter Str 250, D-64293 Darmstadt, Germany
[6] Sanofi R&D, Integrated Drug Discovery Ind Pk Hochst,Bldg G838, D-65926 Frankfurt, Germany
[7] Ludwig Maximilians Univ Munchen, Dept Pharm, Butenandtstr 5-13, D-81377 Munich, Germany
[8] Univ Tubingen, Inst Biomed Engn, Fac Med, Morgenstelle 8, D-72076 Tubingen, Germany
[9] Univ Tubingen, Inst Pharmaceut Sci, Pharmaceut Med Chem Dept, Morgenstelle 8, D-72076 Tubingen, Germany
[10] Univ Leipzig, Inst Drug Discovery, Fac Med, Bruderstr 34, D-04103 Leipzig, Germany
关键词
medicinal chemistry; conference; drug discovery; drug design; chemical biology; PROTEIN-COUPLED RECEPTOR; FACTOR B INHIBITOR; MOLECULAR DESIGN; HALOGEN BONDS; SIDE-CHAINS; DISCOVERY; OPTIMIZATION; CLONING; POTENT; DERIVATIVES;
D O I
10.1002/cmdc.202400543
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The Frontiers in Medicinal Chemistry (FiMC) is the largest international Medicinal Chemistry conference in Germany and took place from March 17th to 20th 2024 in Munich. Co-organized by the Division of Medicinal Chemistry of the German Chemical Society (Gesellschaft Deutscher Chemiker; GDCh) and the Division of Pharmaceutical and Medicinal Chemistry of the German Pharmaceutical Society (Deutsche Pharmazeutische Gesellschaft; DPhG), and supported by a local organizing committee from the Ludwigs-Maximilians-University Munich headed by Daniel Merk, the meeting brought together approximately 225 participants from 20 countries. The outstanding program of the four-day conference included 40 lectures by leading scientists from industry and academia as well as early career investigators. Moreover, 100 posters were presented in two highly interactive poster sessions.
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页数:14
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  • [41] Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3s/ERa Protein-Protein Interaction from Nonselective Fragments
    Konstantinidou, Markella
    Visser, Emira J.
    Vandenboorn, Edmee
    Chen, Sheng
    Jaishankar, Priyadarshini
    Overmans, Maurits
    Dutta, Shubhankar
    Neitz, R. Jeffrey
    Renslo, Adam R.
    Ottmann, Christian
    Brunsveld, Luc
    Arkin, Michelle R.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 145 (37) : 20328 - 20343
  • [42] Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action
    Korff, Marvin
    Imberg, Lukas
    Will, Jonas M.
    Bueckreiss, Nico
    Kalinina, Svetlana A.
    Wenzel, Benjamin M.
    Kastner, Gregor A.
    Daniliuc, Constantin G.
    Barth, Maximilian
    Ovsepyan, Ruzanna A.
    Butov, Kirill R.
    Humpf, Hans-Ulrich
    Lehr, Matthias
    Panteleev, Mikhail A.
    Poso, Antti
    Karst, Uwe
    Steinmetzer, Torsten
    Bendas, Gerd
    Kalinin, Dmitrii, V
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (21) : 13159 - 13186
  • [43] Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells
    Kuehn, Benjamin
    Brat, Camilla
    Fettel, Jasmin
    Hellmuth, Nadine
    Maucher, Isabelle V.
    Bulut, Ufuk
    Hock, Katharina J.
    Grimmer, Jennifer
    Manolikakes, Georg
    Ruehl, Michael
    Kuehn, Alessa
    Zacharowski, Kai
    Matrone, Carmela
    Urbschat, Anja
    Roos, Jessica
    Steinhilber, Dieter
    Maier, Thorsten J.
    [J]. BIOCHEMICAL PHARMACOLOGY, 2018, 155 : 48 - 60
  • [44] Synthesis and in vitro Metabolic Stability of Sterically Shielded Antimycobacterial Phenylalanine Amides
    Lang, Markus
    Ganapathy, Uday S.
    Mann, Lea
    Seidel, Ruediger W.
    Goddard, Richard
    Erdmann, Frank
    Dick, Thomas
    Richter, Adrian
    [J]. CHEMMEDCHEM, 2024, 19 (06)
  • [45] Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria
    Lang, Markus
    Ganapathy, Uday S.
    Mann, Lea
    Abdelaziz, Rana
    Seidel, Rudiger W.
    Goddard, Richard
    Sequenzia, Ilaria
    Hoenke, Sophie
    Schulze, Philipp
    Aragaw, Wassihun Wedajo
    Csuk, Rene
    Dick, Thomas
    Richter, Adrian
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (07) : 5079 - 5098
  • [46] Targeting Histidine Side Chains in Molecular Design through Nitrogen-Halogen Bonds
    Lange, Andreas
    Zirnmermann, Markus O.
    Wilcken, Rainer
    Zahn, Stefan
    Boeckler, Frank M.
    [J]. JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2013, 53 (12) : 3178 - 3189
  • [47] Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor. Agonists/Soluble Epoxide Hydrolase Inhibitors
    Lillich, Felix F.
    Willems, Sabine
    Ni, Xiaomin
    Kilu, Whitney
    Borkowsky, Carmen
    Brodsky, Mirko
    Kramer, Jan S.
    Brunst, Steffen
    Hernandez-Olmos, Victor
    Heering, Jan
    Schierle, Simone
    Kestner, Roxane-, I
    Mayser, Franziska M.
    Helmstaedter, Moritz
    Goebel, Tamara
    Weizel, Lilia
    Namgaladze, Dmitry
    Kaiser, Astrid
    Steinhilber, Dieter
    Pfeilschifter, Waltraud
    Kahnt, Astrid S.
    Proschak, Anna
    Chaikuad, Apirat
    Knapp, Stefan
    Merk, Daniel
    Proschak, Ewgenij
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (23) : 17259 - 17276
  • [48] Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases
    Mainolfi, Nello
    Ehara, Takeru
    Karki, Rajeshri G.
    Anderson, Karen
    Mac Sweeney, Aengus
    Liao, Sha-Mei
    Argikar, Upendra A.
    Jendza, Keith
    Zhang, Chun
    Powers, James
    Klosowski, Daniel W.
    Crowley, Maura
    Kawanami, Toshio
    Ding, Jian
    April, Myriam
    Forster, Cornelia
    Serrano-Wu, Michael
    Capparelli, Michael
    Ramqaj, Rrezarta
    Solovay, Catherine
    Cumin, Frederic
    Smith, Thomas M.
    Ferrara, Luciana
    Lee, Wendy
    Long, Debby
    Prentiss, Melissa
    De Erkenez, Andrea
    Yang, Louis
    Liu, Fang
    Sellner, Holger
    Sirockin, Finton
    Valeur, Eric
    Erbel, Paulus
    Ostermeier, Daniela
    Ramage, Paul
    Gerhartz, Bernd
    Schubart, Anna
    Flohr, Stefanie
    Gradoux, Nathalie
    Feifel, Roland
    Vogg, Barbara
    Wiesmann, Christian
    Maibaum, Juergen
    Eder, Joerg
    Sedrani, Richard
    Harrison, Richard A.
    Mogi, Muneto
    Jaffee, Bruce D.
    Adams, Christopher M.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (11) : 5697 - 5722
  • [49] CLONING OF HUMAN GENES ENCODING NOVEL G-PROTEIN-COUPLED RECEPTORS
    MARCHESE, A
    DOCHERTY, JM
    NGUYEN, T
    HEIBER, M
    CHENG, R
    HENG, HHQ
    TSUI, LC
    SHI, XM
    GEORGE, SR
    ODOWD, BF
    [J]. GENOMICS, 1994, 23 (03) : 609 - 618
  • [50] Tepotinib: First Approval
    Markham, Anthony
    [J]. DRUGS, 2020, 80 (08) : 829 - 833