The Risk of Sympathetic Ophthalmia Associated with Open-Globe Injury Management Strategies A Meta-analysis

被引：2

作者：

Patterson, Tim J. ^{[1
]}

Kedzierski, Adam ^{[2
]}

McKinney, David ^{[1
]}

Ritson, Jonathan ^{[3
,4
]}

Mclean, Chris ^{[5
]}

Gu, Weidong ^{[6
]}

Colyer, Marcus ^{[7
]}

McClellan, Scott F. ^{[6
]}

Miller, Sarah C. ^{[8
]}

Justin, Grant A. ^{[7
,9
]}

Hoskin, Annette K. ^{[10
,11
]}

Cavuoto, Kara ^{[12
]}

Leong, James ^{[10
,13
]}

Ascarza, Andres Rousselot ^{[14
]}

Woreta, Fasika A. ^{[8
]}

Miller, Kyle E. ^{[7
,15
]}

Caldwell, Matthew C. ^{[16
]}

Gensheimer, William G. ^{[17
,18
]}

Williamson, Tom ^{[19
]}

Dhawahir-Scala, Felipe ^{[20
]}

Shah, Peter ^{[21
,22
]}

Coombes, Andrew ^{[23
]}

Sundar, Gangadhara ^{[24
]}

Mazzoli, Robert A. ^{[7
]}

Woodcock, Malcolm ^{[25
]}

Watson, Stephanie L. ^{[13
]}

Kuhn, Ferenc ^{[26
]}

Halliday, Sophia ^{[27
]}

Gomes, Renata S. M. ^{[27
,28
]}

Agrawal, Rupesh ^{[29
,30
,31
,32
]}

Blanch, Richard J. ^{[22
,33
,34
]}

机构：

[1] Northern Ireland Med & Dent Training Agcy NIMDTA, Beflast, North Ireland

[2] Frimley Hlth NHS Trust, Frimley, England

[3] Cambridge Univ Hosp NHS Trust, Cambridge, England

[4] Royal Ctr Def Med, Birmingham, England

[5] Epsom & St Helier Univ Hosp NHS Trust, Epsom, England

[6] Vis Ctr Excellence Res & Dev Directorate, Def Hlth Agcy, J-9, Silver Spring, MD USA

[7] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA

[8] Johns Hopkins Univ, Wilmer Eye Inst, Sch Med, Baltimore, MD USA

[9] Duke Univ Hosp, Duke Eye Ctr, Durham, NC USA

[10] Univ Sydney, Save Sight Inst, Sydney Med Sch, Discipline Ophthalmol, Sydney, NSW, Australia

[11] Univ Western Australia, Lions Eye Inst, Perth, Australia

[12] Univ Miami, Bascom Palmer Eye Inst, Leonard M Miller Sch Med, Miami, FL USA

[13] Univ Sydney, Save Sight Inst, Fac Med & Hlth, Sydney, NSW, Australia

[14] Consultorios Oftalmol Benisek Ascarza, Ciudad Autonoma De Buenos, Buenos Aires, Argentina

[15] Navy Med Ctr Portsmouth, Dept Ophthalmol, Portsmouth, VA USA

[16] San Antonio Uniformed Serv Hlth Educ Consortium, Dept Ophthalmol, San Antonio, TX USA

[17] Dartmouth Hitchcock Med Ctr, Lebanon, NH USA

[18] White River Junct Vet Adm Med Ctr, White River Jct, VT USA

[19] St Thomas Hosp, Dept Ophthalmol, London, England

[20] Manchester Royal Eye Hosp, Manchester, England

[21] Birmingham Inst Glaucoma Res, Birmingham, England

[22] Univ Hosp Birmingham NHS Fdn Trust, Dept Ophthalmol, Birmingham, England

[23] Barts Hlth NHS Trust, Royal London Hosp, Dept Ophthalmol, London, England

[24] Natl Univ Singapore Hosp, Dept Ophthalmol, Singapore, Singapore

[25] Worcestershire Acute Hosp NHS Trust, Worcester, England

[26] Helen Keller Fdn Res & Educ, Birmingham, AL USA

[27] BRAVO VICTOR, Res & Innovat, London, England

[28] Northumbria Univ, Northern Hub Vet & Mil Families Res, Newcastle, England

[29] Tan Tock Seng Hosp, Natl Healthcare Grp Eye Inst, Singapore, Singapore

[30] Singapore Eye Res Inst, Singapore, Singapore

[31] Lee Kong Chian Sch Med, Singapore, Singapore

[32] Duke NUS Med Sch, Singapore, Singapore

[33] Univ Birmingham, Inst Inflammat & Ageing, Coll Med & Dent Sci, Neurosci & Ophthalmol, Birmingham, England

[34] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, England

来源：

OPHTHALMOLOGY | 2024年 / 131卷 / 05期

基金：

英国惠康基金;

关键词：

Epidemiology; Sympathetic ophthalmia; Trauma; Uveitis;

D O I：

10.1016/j.ophtha.2023.12.006

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Topic: Sympathetic ophthalmia (SO) is a sight-threatening granulomatous panuveitis caused by a sensitizing event. Primary enucleation or primary evisceration, versus primary repair, as a risk management strategy after open-globe injury (OGI) remains controversial. Clinical Relevance: This systematic review was conducted to report the incidence of SO after primary repair compared with that of after primary enucleation or primary evisceration. This enabled the reporting of an estimated number needed to treat. Methods: Five journal databases were searched. This review was registered with International Prospective Register of Systematic Reviews (identifier, CRD42021262616). Searches were carried out on June 29, 2021, and were updated on December 10, 2022. Prospective or retrospective studies that reported outcomes (including SO or lack of SO) in a patient population who underwent either primary repair and primary enucleation or primary evisceration were included. A systematic review and meta-analysis were carried out in accordance with Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Random effects modelling was used to estimate pooled SO rates and absolute risk reduction (ARR). Results: Eight studies reporting SO as an outcome were included in total. The included studies contained 7500 patients and 7635 OGIs. In total, 7620 OGIs met the criteria for inclusion in this analysis; SO developed in 21 patients with OGI. When all included studies were pooled, the estimated SO rate was 0.12% (95% confidence interval [CI], 0.00%-0.25%) after OGI. Of 779 patients who underwent primary enucleation or primary evisceration, no SO cases were reported, resulting in a pooled SO estimate of 0.05% (95% CI, 0.00%-0.21%). For primary repair, the pooled estimate of SO rate was 0.15% (95% CI, 0.00%-0.33%). The ARR using a random effects model was-0.0010 (in favour of eye removal; 95% CI,-0.0031 [in favor of eye removal] to 0.0011 [in favor of primary repair]). Grading of Recommendations, Assessment, Development, and Evaluations analysis highlighted a low certainty of evidence because the included studies were observational, and a risk of bias resulted from missing data. Discussion: Based on the available data, no evidence exists that primary enucleation or primary evisceration reduce the risk of secondary SO. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Ophthalmology 2024;131:557-567 (c) 2023 by the American Academy of Ophthalmology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

引用

页码：557 / 567

页数：11

共 30 条

[1] A HISTORICAL REVIEW OF SYMPATHETIC OPHTHALMIA AND ITS EPIDEMIOLOGY
ALBERT, DM
DIAZROHENA, R
[J]. SURVEY OF OPHTHALMOLOGY, 1989, 34 (01) : 1 - 14
[2] [Anonymous], 2020, Prospero Systematic Review Database
[3] A 10-year review of assault-related open-globe injuries at an urban hospital
Bauza, Alain M.
Emami, Parisa
Soni, Nishant
Holland, Bart K.
Langer, Paul
Zarbin, Marco
Bhagat, Neelakshi
[J]. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2013, 251 (03) : 653 - 659
[4] Bellan L, 1999, CAN J OPHTHALMOL, V34, P95
[5] Sympathetic ophthalmia: a review of literature
Chaithanyaa, Nemaly
Devireddy, Sathya Kumar
Kumar, R. V. Kishore
Gali, Raja Sekhar
Aneja, Vikas
[J]. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 2012, 113 (02): : 172 - 176
[6] Sympathetic Ophthalmia
Chang, Grace C.
Young, Lucy H.
[J]. SEMINARS IN OPHTHALMOLOGY, 2011, 26 (4-5) : 316 - 320
[7] Chang HC, 2016, J Med Sci, V36, P131
[8] Sympathetic ophthalmia: To the twenty-first century and beyond
Chu X.K.
Chan C.-C.
[J]. Journal of Ophthalmic Inflammation and Infection, 3 (1) : 1 - 9
[9] Cochrane Collaboration, 2023, Cochrane Handbook
[10] Perforating Globe Injuries during Operation Iraqi Freedom
Colyer, Marcus H.
Chun, Dal W.
Bower, Kraig S.
Dick, John S. B.
Weichel, Eric D.
[J]. OPHTHALMOLOGY, 2008, 115 (11) : 2087 - 2093

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