Comprehensive review on the novel immunotherapy target: Leucine-rich repeat-containing 8A/volume-regulated anion channel

被引：0
|
作者：
Hu, Yaohua [1 ,2 ]
Qin, Jing [1 ]
Ma, Yifan [1 ,3 ]
Yang, Runze [1 ,3 ]
Liu, Xinyu [1 ,4 ]
Shi, Changhong [1 ,5 ]
机构：
[1] Fourth Mil Med Univ, Lab Anim Ctr, Div Canc Biol, Xian 710032, Shaanxi, Peoples R China
[2] Yanan Univ, Dept Pathol, Affiliated Hosp, Yanan 716000, Shaanxi, Peoples R China
[3] Gansu Univ Tradit Chinese Med, Lanzhou 730030, Peoples R China
[4] Yanan Univ, Sch Basic Med Sci, Med Coll, 580 Bao Ta St, Yanan 716000, Shaanxi, Peoples R China
[5] Fourth Mil Med Univ, Lab Anim Ctr, Div Canc Biol, Xian 710032, Shaanxi, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2024年 / 20卷 / 10期
基金：
中国国家自然科学基金;
关键词：
leucine-rich repeat-containing 8A (LRRC8A); volume-regulated anion channel (VRAC); immunotherapy; tumor; virus; PROTEIN-TYROSINE PHOSPHORYLATION; CELL-VOLUME REGULATION; ESSENTIAL COMPONENT; IMMUNE SUPPRESSION; LRRC8; HETEROMERS; ION CHANNELS; ACTIVATION; IDENTIFICATION; TRANSPORTERS; MECHANISMS;
D O I：
10.7150/ijbs.95933
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Leucine-rich repeat-containing 8A (LRRC8A) is a key component of the volume-regulated anion channel (VRAC) that influences essential homeostatic processes in various immune cells. These processes include the regulation of cell volume and membrane potential and the facilitation of the transport of organic agents used as anticancer drugs and immune-stimulating factors. Therefore, understanding the structure-function relationship of LRRC8A, exploring its physiological role in immunity, assessing its efficacy in treating diseases, and advancing the development of compounds that regulate its activity are important research frontiers. This review emphasized the emerging field of LRRC8A, outlined its structure and function, and summarized its role in immune cell development and immune cell-mediated antiviral and antitumor effects. Additionally, it explored the potential of LRRC8A as an immunotherapeutic target, offering insights into resolving persistent challenges and future research directions.
引用
收藏
页码：3881 / 3891
页数：11
相关论文
共 42 条
  • [1] Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function
    Platt, Craig D.
    Chou, Janet
    Houlihan, Patrick
    Badran, Yousef R.
    Kumar, Lalit
    Bainter, Wayne
    Poliani, P. Luigi
    Perez, Carlos J.
    Dent, Sharon Y. R.
    Clapham, David E.
    Benavides, Fernando
    Geha, Raif S.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (06) : 1651 - +
  • [2] Paclitaxel induces pyroptosis by inhibiting the volume-sensitive chloride channel leucine-rich repeat-containing 8a in ovarian cancer cells
    Yang, Xiurou
    Li, Chao
    Liao, Xuzhen
    Liu, Shiqing
    Li, Xue
    Hou, Xiuying
    Wang, Kai
    Yang, Haifeng
    Gao, Lvfen
    Zhu, Linyan
    ONCOLOGY REPORTS, 2023, 49 (06)
  • [3] Chloride Channel-3 (ClC-3) Modifies the Trafficking of Leucine-Rich Repeat-Containing 8A (LRRC8A) Anion Channels
    Ryan J. Stark
    Hong N. Nguyen
    Matthew K. Bacon
    Jeffrey C. Rohrbough
    Hyehun Choi
    Fred S. Lamb
    The Journal of Membrane Biology, 2023, 256 : 125 - 135
  • [4] Chloride Channel-3 (ClC-3) Modifies the Trafficking of Leucine-Rich Repeat-Containing 8A (LRRC8A) Anion Channels
    Stark, Ryan J.
    Nguyen, Hong N.
    Bacon, Matthew K.
    Rohrbough, Jeffrey C.
    Choi, Hyehun
    Lamb, Fred S.
    JOURNAL OF MEMBRANE BIOLOGY, 2023, 256 (02): : 125 - 135
  • [5] Expression and role of Leucine-Rich Repeat-Containing protein 8A in esophageal squamous cell carcinoma
    Konishi, Tomoki
    Shiozaki, Atsushi
    Kudou, Michihiro
    Shoda, Katsutoshi
    Arita, Tomohiro
    Kosuga, Toshiyuki
    Konishi, Hirotaka
    Komatsu, Shuhei
    Kubota, Takeshi
    Fujiwara, Hitoshi
    Okamoto, Kazuma
    Kishimoto, Mitsuo
    Otsuji, Eigo
    CANCER SCIENCE, 2018, 109 : 217 - 217
  • [6] A new comprehensive annotation of leucine-rich repeat-containing receptors in rice
    Gottin, Celine
    Dievart, Anne
    Summo, Marilyne
    Droc, Gaetan
    Perin, Christophe
    Ranwez, Vincent
    Chantret, Nathalie
    PLANT JOURNAL, 2021, 108 (02): : 492 - 508
  • [7] The expression and significance of Leucine-Rich Repeat-Containing protein 8A (LRRC8A) in Gastric cancer.
    Kurashima, Kento
    Shiozaki, Atsushi
    Kosuga, Toshiyuki
    Shimizu, Hiroki
    Kudou, Michihiro
    Arita, Tomohiro
    Yamamoto, Yusuke
    Konishi, Hirotaka
    Morimura, Ryo
    Kuriu, Yoshiaki
    Ikoma, Hisashi
    Kubota, Takeshi
    Fujiwara, Hitoshi
    Okamoto, Kazuma
    Otsuji, Eigo
    CANCER SCIENCE, 2021, 112 : 628 - 628
  • [8] Downregulation of Leucine-Rich Repeat-Containing 8A Limits Proliferation and Increases Sensitivity of Glioblastoma to Temozolomide and Carmustine
    Rubino, Sebastian
    Bach, Martin D.
    Schober, Alexandra L.
    Lambert, Ian H.
    Mongin, Alexander A.
    FRONTIERS IN ONCOLOGY, 2018, 8
  • [9] BK potassium channel modulation by leucine-rich repeat-containing proteins
    Yan, Jiusheng
    Aldrich, Richard W.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (20) : 7917 - 7922
  • [10] Comprehensive review on leucine-rich pentatricopeptide repeat-containing protein (LRPPRC, PPR protein): A burgeoning target for cancer therapy
    Ge, Yunxiao
    Janson, Victor
    Liu, Hui
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 282
12345