Neutralizing Autoantibodies against Interleukin-10 in Inflammatory Bowel Disease

被引：6

作者：

Griffin, Helen ^{[1
]}

Ceron-Gutierrez, Lourdes ^{[3
]}

Gharahdaghi, Nima ^{[5
]}

Ebrahimi, Soraya ^{[3
]}

Davies, Sophie ^{[3
]}

Loo, Peh Sun ^{[2
]}

Szabo, Andras ^{[8
,11
]}

Williams, Eleri ^{[2
]}

Mukhopadhyay, Anirban ^{[2
]}

Mcloughlin, Louise ^{[8
]}

Irwin, Steven ^{[9
]}

Travis, Simon ^{[5
,6
]}

Klenerman, Paul ^{[5
,6
]}

Bunn, Su ^{[10
]}

Cant, Andrew J. ^{[2
]}

Hambleton, Sophie ^{[1
,2
]}

Uhlig, Holm H. ^{[5
,6
,7
]}

Doffinger, Rainer ^{[3
,4
]}

机构：

[1] Newcastle Univ, Translat & Clin Res Inst, Immun & Inflammat Theme, Leech Bldg M3 136D Framlington Pl, Newcastle upon Tyne NE2 4HH, England

[2] Newcastle Tyne Hosp NHS Fdn Trust, Great North Childrens Hosp, Newcastle upon Tyne, England

[3] Cambridge Univ Hosp, Dept Clin Biochem & Immunol, Cambridge, England

[4] Natl Inst Hlth & Care Res NIHR, Cambridge Biomed Res Ctr, Cambridge, England

[5] Univ Oxford, Kennedy Inst Rheumatol, Translat Gastroenterol Unit, Oxford, England

[6] Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, England

[7] Univ Oxford, Dept Pediat, Oxford, England

[8] Royal Belfast Hosp Sick Children, Dept Pediat Gastroenterol, Belfast, North Ireland

[9] Belfast Hlth & Social Care Trust, Royal Victoria Hosp, Dept Pathol, Belfast, North Ireland

[10] Royal Aberdeen Childrens Hosp, Dept Pediat Gastroenterol, Aberdeen, Scotland

[11] Pal Heim Natl Pediat Inst, Pediat Gastroenterol Dept, Budapest, Hungary

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2024年 / 391卷 / 05期

基金：

英国惠康基金;

关键词：

PULMONARY ALVEOLAR PROTEINOSIS; ANTIBODY; GENE;

D O I：

10.1056/NEJMoa2312302

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We discovered high-titer neutralizing autoantibodies against interleukin-10 in a child with infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin-10 signaling. After B-cell-depletion therapy and an associated decrease in the anti-interleukin-10 titer, conventional IBD therapy could be withdrawn. A second child with neutralizing anti-interleukin-10 autoantibodies had a milder course of IBD and has been treated without B-cell depletion. We conclude that neutralizing anti-interleukin-10 autoantibodies may be a causative or modifying factor in IBD, with potential implications for therapy. (Funded by the National Institute for Health and Care Research and others.) Two children with inflammatory bowel disease had neutralizing anti-interleukin-10 autoantibodies. One child had durable drug-free remission after B-cell depletion and an associated decrease in the anti-interleukin-10 titer.

引用

页码：434 / 441

页数：8

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