Journey through discovery of 75 years glucocorticoids: evolution of our knowledge of glucocorticoid receptor mechanisms in rheumatic diseases

被引:5
作者
Eiers, Ann-Kathrin [1 ]
Vettorazzi, Sabine [1 ]
Tuckermann, Jan P. [1 ]
机构
[1] Ulm Univ, Inst Comparat Mol Endocrinol, Ulm, Germany
关键词
Glucocorticoids; Arthritis; Rheumatoid; Inflammation; DNA-BINDING; CHROMATIN ACCESSIBILITY; TRANSCRIPTION FACTORS; LUNG INJURY; MOUSE MODEL; ANNEXIN A1; C-JUN; ARTHRITIS; BONE; INHIBITION;
D O I
10.1136/ard-2023-225371
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
For three-quarters of a century, glucocorticoids (GCs) have been used to treat rheumatic and autoimmune diseases. Over these 75 years, our understanding of GCs binding to nuclear receptors, mainly the glucocorticoid receptor (GR) and their molecular mechanisms has changed dramatically. Initially, in the late 1950s, GCs were considered important regulators of energy metabolism. By the 1970s/1980s, they were characterised as ligands for hormone-inducible transcription factors that regulate many aspects of cell biology and physiology. More recently, their impact on cellular metabolism has been rediscovered. Our understanding of cell-type-specific GC actions and the crosstalk between various immune and stromal cells in arthritis models has evolved by investigating conditional GR mutant mice using the Cre/LoxP system. A major achievement in studying the complex, cell-type-specific interplay is the recent advent of omics technologies at single-cell resolution, which will provide further unprecedented insights into the cell types and factors mediating GC responses. Alongside gene-encoded factors, anti-inflammatory metabolites that participate in resolving inflammation by GCs during arthritis are just being uncovered. The translation of this knowledge into therapeutic concepts will help tackle inflammatory diseases and reduce side effects. In this review, we describe major milestones in preclinical research that led to our current understanding of GC and GR action 75 years after the first use of GCs in arthritis.
引用
收藏
页码:1603 / 1613
页数:11
相关论文
共 152 条
[1]   Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1 [J].
Abraham, Sonya M. ;
Lawrence, Toby ;
Kleiman, Anna ;
Warden, Paul ;
Medghalchi, Mino ;
Tuckermann, Jan ;
Saklatvala, Jeremy ;
Clark, Andrew R. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (08) :1883-1889
[2]   Glucocorticoid Nanoparticles Show Full Therapeutic Efficacy in a Mouse Model of Acute Lung Injury and Concomitantly Reduce Adverse Effects [J].
Albers, Gesa J. ;
Amouret, Agathe ;
Ciupka, Katrin ;
Montes-Cobos, Elena ;
Feldmann, Claus ;
Reichardt, Holger M. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (23)
[3]   Diagnosis and Management of Rheumatoid Arthritis A Review [J].
Aletaha, Daniel ;
Smolen, Josef S. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2018, 320 (13) :1360-1372
[4]   Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids [J].
Auger, Jean-Philippe ;
Zimmermann, Max ;
Faas, Maria ;
Stifel, Ulrich ;
Chambers, David ;
Krishnacoumar, Brenda ;
Taudte, R. Verena ;
Grund, Charlotte ;
Erdmann, Gitta ;
Scholtysek, Carina ;
Uderhardt, Stefan ;
Ben Brahim, Oumaima ;
Mate, Monica Pascual ;
Stoll, Cornelia ;
Boettcher, Martin ;
Palumbo-Zerr, Katrin ;
Mangan, Matthew S. J. ;
Dzamukova, Maria ;
Kieler, Markus ;
Hofmann, Melanie ;
Blueml, Stephan ;
Schabbauer, Gernot ;
Mougiakakos, Dimitrios ;
Sonnewald, Uwe ;
Hartmann, Fabian ;
Simon, David ;
Kleyer, Arnd ;
Grueneboom, Anika ;
Finotto, Susetta ;
Latz, Eicke ;
Hofmann, Joerg ;
Schett, Georg ;
Tuckermann, Jan ;
Kroenke, Gerhard .
NATURE, 2024, 629 (8010) :184-+
[5]   Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells [J].
Baschant, Ulrike ;
Frappart, Lucien ;
Rauchhaus, Una ;
Bruns, Lisa ;
Reichardt, Holger M. ;
Kamradt, Thomas ;
Braeuer, Rolf ;
Tuckermann, Jan P. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (48) :19317-19322
[6]   The glucocorticoid receptor is required for stress erythropoiesis [J].
Bauer, A ;
Tronche, F ;
Wessely, O ;
Kellendonk, C ;
Reichardt, HM ;
Steinlein, P ;
Schütz, G ;
Beug, H .
GENES & DEVELOPMENT, 1999, 13 (22) :2996-3002
[7]   STEROID-HORMONE RECEPTORS - MANY ACTORS IN SEARCH OF A PLOT [J].
BEATO, M ;
HERRLICH, P ;
SCHUTZ, G .
CELL, 1995, 83 (06) :851-857
[8]   Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding [J].
Biddie, Simon C. ;
John, Sam ;
Sabo, Pete J. ;
Thurman, Robert E. ;
Johnson, Thomas A. ;
Schiltz, R. Louis ;
Miranda, Tina B. ;
Sung, Myong-Hee ;
Trump, Saskia ;
Lightman, Stafford L. ;
Vinson, Charles ;
Stamatoyannopoulos, John A. ;
Hager, Gordon L. .
MOLECULAR CELL, 2011, 43 (01) :145-155
[9]   Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition [J].
Bledsoe, RK ;
Montana, VG ;
Stanley, TB ;
Delves, CJ ;
Apolito, CJ ;
McKee, DD ;
Consler, TG ;
Parks, DJ ;
Stewart, EL ;
Willson, TM ;
Lambert, MH ;
Moore, JT ;
Pearce, KH ;
Xu, HE .
CELL, 2002, 110 (01) :93-105
[10]  
Bothe M, 2021, bioRxiv, DOI [10.1101/2021.01.05.425406, 10.1101/2021.01.05.425406, DOI 10.1101/2021.01.05.425406]