Reduced cell-mediated immune response in hyperglycemic NOD mice following influenza vaccination

被引：0

作者：

Bang, Ji Young ^{[1
]}

Kim, Yun Ji ^{[1
]}

Seo, Young-Jin ^{[2
]}

Hong, So-Hee ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Med, Dept Microbiol, Seoul 078040, South Korea

[2] Chung Ang Univ, Dept Life Sci, 84 Heukseok Ro, Seoul 06974, South Korea

来源：

VACCINE | 2024年 / 42卷 / 25期

基金：

新加坡国家研究基金会;

关键词：

Type; 1; diabetes; Hyperglycemia; Nonobese diabetic mice; Influenza vaccine; Cell-mediated immune response; DIABETES-MELLITUS; TYPE-1; GLUCOSE; RISK; INFECTION;

D O I：

10.1016/j.vaccine.2024.07.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Due to the higher risk of medical complications posed by influenza infection, patients with type 1 diabetes (T1D) are strongly recommended to receive the influenza vaccine. However, it remains unclear if hyperglycemia in patients with T1D affects vaccine-induced immune responses. In this study, we investigated the humoral and cellular immune responses of prediabetic and diabetic, nonobese diabetic (NOD) mice following influenza vaccination to determine the effects of hyperglycemia on influenza vaccine-induced responses. In diabetic NOD mice, vaccine-specific IgG and IgM levels, as well as IgG-producing cells, were comparable to those in prediabetic NOD mice. However, the diabetic NOD mice exhibited reduced percentages of memory T cells and activated T cells in the spleen, along with reduced number of vaccine-specific interferon (IFN)-gamma-secreting cells. Thus, these findings suggest that in patients with T1D, hyperglycemia could lead to impaired cell-mediated immune responses following influenza vaccination.

引用

页数：5

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