RNA in cardiovascular disease: A new frontier of personalized medicine

被引：1

作者：

Abdul-Rahman, Toufik ^{[1
]}

Lizano-Jubert, Ileana ^{[2
]}

Bliss, Zarah Sophia Blake ^{[2
]}

Garg, Neil ^{[3
]}

Meale, Emily ^{[3
]}

Roy, Poulami ^{[4
]}

Crino, Salvatore Antonio ^{[5
]}

Deepak, Bethineedi Lakshmi ^{[6
]}

Miteu, Goshen David ^{[7
]}

Wireko, Andrew Awuah ^{[1
]}

Qadeer, Abdul ^{[8
]}

Condurat, Alexandra ^{[9
]}

Tanasa, Andra Diana ^{[9
]}

Pyrpyris, Nikolaos ^{[10
]}

Sikora, Kateryna ^{[1
]}

Horbas, Viktoriia ^{[1
]}

Sood, Aayushi ^{[11
]}

Gupta, Rahul ^{[12
]}

Lavie, Carl J. ^{[13
,14
]}

机构：

[1] Sumy State Univ, Med Inst, Sumy, Ukraine

[2] Anahuac Univ, Fac Med, North Campus, Huixquilucan, Mexico

[3] Rowan Virtua Sch Osteopath Med, Stratford, NJ USA

[4] North Bengal Med Coll & Hosp, Dept Med, Siliguri, India

[5] Humanitas Univ, Dept Biomed Sci, Pieve Emanuele, MI, Italy

[6] Andhra Med Coll, Dept Med, Visakhapatnam, Andhra Pradesh, India

[7] Univ Nottingham, Sch Biosci, Nottingham, England

[8] Mayo Clin, Hosp Internal Med Dept, Scottsdale, AZ USA

[9] Univ Med & Pharm Grigore T Popa, Iasi, Romania

[10] Natl & Kapodistrian Univ Athens, Hippokration Gen Hosp, Sch Med, Dept Cardiol 1, Athens, Greece

[11] Wright Ctr Grad Med Educ, Dept Med, Scranton, PA USA

[12] Lehigh Valley Hlth Network, Lehigh Valley Heart & Vasc Inst, Allentown, PA 18103 USA

[13] Ochsner Clin Fdn, Dept Cardiol, New Orleans, LA USA

[14] Univ Queensland, Med Sch, Ochsner Clin Sch, New Orleans, LA USA

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2024年 / 85卷

关键词：

RNA; Cardiovascular diseases; Personalized medicine; DILATED CARDIOMYOPATHY; GENE-TRANSFER; VEGF-A; THERAPEUTICS; OLIGONUCLEOTIDES; POTENTIALS; MIPOMERSEN; INHIBITORS; CHALLENGES; THERAPIES;

D O I：

10.1016/j.pcad.2024.01.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Personalized medicine has witnessed remarkable progress with the emergence of RNA therapy, offering new possibilities for the treatment of various diseases, and in particular in the context of cardiovascular disease (CVD). The ability to target the human genome through RNA manipulation offers great potential not only in the treatment of cardiac pathologies but also in their diagnosis and prevention, notably in cases of hyperlipidemia and myocardial infarctions. While only a few RNA-based treatments have entered clinical trials or obtained approval from the US Food and Drug Administration, the growing body of research on this subject is promising. However, the development of RNA therapies faces several challenges that must be overcome. These include the efficient delivery of drugs into cells, the potential for immunogenic responses, and safety. Resolving these obstacles is crucial to advance the development of RNA therapies. This review explores the newest developments in medical studies, treatment plans, and results related to RNA therapies for heart disease. Furthermore, it discusses the exciting possibilities and difficulties in this innovative area of research.

引用

页码：93 / 102

页数：10

共 91 条

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