The Role of Short Chain Fatty Acids in Inflammation and Body Health

被引：78

作者：

Du, Yuhang ^{[1
]}

He, Changhao ^{[1
]}

An, Yongcheng ^{[1
]}

Huang, Yan ^{[2
]}

Zhang, Huilin ^{[1
]}

Fu, Wanxin ^{[2
]}

Wang, Menglu ^{[1
]}

Shan, Ziyi ^{[2
]}

Xie, Jiamei ^{[1
]}

Yang, Yang ^{[1
]}

Zhao, Baosheng ^{[3
]}

机构：

[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Dept Pharmacol Chinese Mat Med, Beijing 102488, Peoples R China

[2] Beijing Univ Chinese Med, Coll Life Sci, Beijing 102488, Peoples R China

[3] Beijing Univ Chinese Med, Beijing Res Inst Chinese Med, Beijing 100029, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 13期

基金：

中国国家自然科学基金;

关键词：

short chain fatty acids; gut microbiota; inflammation; signaling pathways; metabolic disease; BUTYRATE-PRODUCING BACTERIA; REGULATORY T-CELLS; SODIUM-BUTYRATE; GUT MICROBIOTA; ENERGY-METABOLISM; INTESTINAL MICROBIOTA; INSULIN-RESISTANCE; RECEPTORS FFA2; DIETARY FIBER; PROPIONATE;

D O I：

10.3390/ijms25137379

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Short chain fatty acids (SCFAs), mainly including acetate, propionate and butyrate, are produced by intestinal bacteria during the fermentation of partially digested and indigestible polysaccharides. SCFAs play an important role in regulating intestinal energy metabolism and maintaining the homeostasis of the intestinal environment and also play an important regulatory role in organs and tissues outside the gut. In recent years, many studies have shown that SCFAs can regulate inflammation and affect host health, and two main signaling mechanisms have also been identified: the activation of G-protein coupled receptors (GPCRs) and inhibition of histone deacetylase (HDAC). In addition, a growing body of evidence highlights the importance of every SCFA in influencing health maintenance and disease development. In this review, we summarized the recent advances concerning the biological properties of SCFAs and their signaling pathways in inflammation and body health. Hopefully, it can provide a systematic theoretical basis for the nutritional prevention and treatment of human diseases.

引用

页数：23

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