The roles of AIM2 in neurodegenerative diseases: insights and therapeutic implications

被引：2

作者：

Yang, Kai ^{[1
,2
]}

Wang, Xi ^{[1
]}

Pan, Hanyu ^{[1
]}

Wang, Xinqing ^{[3
]}

Hu, Yunhan ^{[1
]}

Yao, Yihe ^{[4
]}

Zhao, Xinyue ^{[1
]}

Sun, Taolei ^{[1
,2
,5
]}

机构：

[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan, Peoples R China

[2] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Hubei Key Lab Nanomed Neurodegenerat Dis, Wuhan, Peoples R China

[3] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang, Peoples R China

[4] Wuhan Univ Technol, Inst WUT AMU, Wuhan, Peoples R China

[5] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

基金：

中国国家自然科学基金;

关键词：

inflammasome; AIM2; neurodegenerative disease; Alzheimer's disease; Parkinson's disease; INFLAMMASOME ACTIVATION; INNATE IMMUNITY; MELANOMA; EXPRESSION; RELEASE; ABSENT;

D O I：

10.3389/fimmu.2024.1441385

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

AIM2, a cytosolic innate immune receptor, has the capability to recognize double-stranded DNA (dsDNA). This paper delineates the structural features of AIM2 and its mechanisms of activation, emphasizing its capacity to detect cytosolic DNA and initiate inflammasome assembly. Additionally, we explore the diverse functions of AIM2 in different cells. Insights into AIM2-mediated neuroinflammation provide a foundation for investigating novel therapeutic strategies targeting AIM2 signaling pathways. Furthermore, we present a comprehensive review of the roles of AIM2 in neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Finally, we discuss its therapeutic implications. In conclusion, a profound understanding of AIM2 in neurodegenerative diseases may facilitate the development of effective interventions to mitigate neuronal damage and slow disease progression.

引用

页数：13

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