Association of serum syndecan-1 concentrations with albuminuria in type 2 diabetes

被引：0
|
作者：
Kakutani, Yoshinori [1 ]
Morioka, Tomoaki [1 ]
Yamazaki, Yuko [1 ]
Ochi, Akinobu [1 ]
Fukumoto, Shinya [2 ]
Shoji, Tetsuo [3 ]
Emoto, Masanori [1 ]
机构：
[1] Osaka Metropolitan Univ, Grad Sch Med, Dept Metab Endocrinol & Mol Med, 1-4-3 Asahi Machi,Abeno Ku, Osaka 5458585, Japan
[2] Osaka Metropolitan Univ, Grad Sch Med, Dept Premier Prevent Med, Osaka, Japan
[3] Osaka Metropolitan Univ, Grad Sch Med, Dept Vasc Med, Osaka, Japan
来源：
DIABETES & VASCULAR DISEASE RESEARCH | 2024年 / 21卷 / 04期
关键词：
Albuminuria; endothelial glycocalyx; syndecan-1; type; 2; diabetes; ENDOTHELIAL GLYCOCALYX; DEGRADATION; MELLITUS;
D O I：
10.1177/14791641241278362
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: Syndecan (SDC)-1 is a transmembrane heparan sulfate proteoglycan and is a major component of endothelial glycocalyx (EG). This study aimed to investigate the association of serum SDC-1 concentration as a marker of EG degradation with albuminuria in type 2 diabetes. Methods: We included 370 patients with type 2 diabetes and 219 individuals with no diabetes. The individuals with estimate glomerular filtration rate <30 mL/min/1.73 m(2) were excluded. Results: Serum SDC-1 concentration was higher in type 2 diabetes than in no diabetes. The presence of diabetes was independently associated with log [SDC-1] in multivariate analysis. In type 2 diabetes, serum SDC-1 concentration was correlated with log [urinary albumin-to-creatinine ratio (ACR)]. Moreover, log [SDC-1] was an independent determinant of log [ACR] after adjustment for known risk factors of albuminuria. Conclusions: Serum SDC-1 concentration was higher in patients with type 2 diabetes compared to individuals with no diabetes and an independent determinant of ACR. This study implicates the role of the EG degradation in albuminuria in type 2 diabetes.
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页数：3
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