Association of serum syndecan-1 concentrations with albuminuria in type 2 diabetes

被引：0

作者：

Kakutani, Yoshinori ^{[1
]}

Morioka, Tomoaki ^{[1
]}

Yamazaki, Yuko ^{[1
]}

Ochi, Akinobu ^{[1
]}

Fukumoto, Shinya ^{[2
]}

Shoji, Tetsuo ^{[3
]}

Emoto, Masanori ^{[1
]}

机构：

[1] Osaka Metropolitan Univ, Grad Sch Med, Dept Metab Endocrinol & Mol Med, 1-4-3 Asahi Machi,Abeno Ku, Osaka 5458585, Japan

[2] Osaka Metropolitan Univ, Grad Sch Med, Dept Premier Prevent Med, Osaka, Japan

[3] Osaka Metropolitan Univ, Grad Sch Med, Dept Vasc Med, Osaka, Japan

来源：

DIABETES & VASCULAR DISEASE RESEARCH | 2024年 / 21卷 / 04期

关键词：

Albuminuria; endothelial glycocalyx; syndecan-1; type; 2; diabetes; ENDOTHELIAL GLYCOCALYX; DEGRADATION; MELLITUS;

D O I：

10.1177/14791641241278362

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Syndecan (SDC)-1 is a transmembrane heparan sulfate proteoglycan and is a major component of endothelial glycocalyx (EG). This study aimed to investigate the association of serum SDC-1 concentration as a marker of EG degradation with albuminuria in type 2 diabetes. Methods: We included 370 patients with type 2 diabetes and 219 individuals with no diabetes. The individuals with estimate glomerular filtration rate <30 mL/min/1.73 m(2) were excluded. Results: Serum SDC-1 concentration was higher in type 2 diabetes than in no diabetes. The presence of diabetes was independently associated with log [SDC-1] in multivariate analysis. In type 2 diabetes, serum SDC-1 concentration was correlated with log [urinary albumin-to-creatinine ratio (ACR)]. Moreover, log [SDC-1] was an independent determinant of log [ACR] after adjustment for known risk factors of albuminuria. Conclusions: Serum SDC-1 concentration was higher in patients with type 2 diabetes compared to individuals with no diabetes and an independent determinant of ACR. This study implicates the role of the EG degradation in albuminuria in type 2 diabetes.

引用

页数：3

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