Increased preload and echocardiographic assessment of diastolic function

Aims: Echocardiographic diastolic parameters are used to diagnose and monitor increased left ventricular filling pressure (LVFP) and we hypothesized that increased loading conditions cause increased E/e '. Our aim was to assess the effect of preload augmentation on diastolic parameters among both healthy subjects and subjects with known cardiac disease. Methods and results: We included 129 subjects merged from two cohorts; one dialysis cohort (n = 47) and one infusion cohort (n = 82). Echocardiography was performed immediately before and after hemodialysis (HD) or saline infusion, under low and high loading conditions. Elevated LVFP was defined as septal E/e ' >= 15 and/or lateral E/e ' >= 13 at high-loading conditions. The population was divided according to elevated LVFP (n = 31) and normal LVFP (n = 98). The load difference for the population was 972 +/- 460 mL, with no differences in load difference between elevated and normal LVFP (p NS). The subjects with elevated LVFP were older (63 +/- 11 vs. 46 +/- 16 years, p < .001), and had lower LV ejection fraction (50 +/- 14 vs. 59 +/- 8.1%, p < .01). After augmented preload, EDV increased in the normal LVFP group (p < .01) but remained unchanged in the elevated LVFP group (p NS). Both E and e ' increased among the subjects with normal LVFP, whereas E/e ' remained unchanged (triangle E/e ' +.1 [-.5-1.2]), p NS). Among the subjects with elevated, LVFP we observed increased E but not e ', resulting in significantly increased E/e ' (triangle average E/e ' +2.4 [0-4.0], p < .01). Conclusion: Augmented preload does not seem to affect E/e ' among subjects with normal LVFP, whereas E/e ' seems to increase significantly among subjects with elevated LVFP.