Molecular characterization and frequency of human pegivirus type 1 (HPgV-1) in kidney transplant recipients from Central-West Brazil

被引:0
作者
da Silva, Fabio Goncalves [1 ]
Moura, Drielly Rodrigues [1 ]
de Oliveira, Pamela Maria [1 ,2 ]
Quintao, Tatyane de Souza Cardoso [1 ,2 ]
Cassemiro, evelin Mota [1 ,2 ]
de Campos, Gabriel Montenegro [3 ]
da Silva, Anielly Sarana [3 ]
Bezerra, Rafael dos Santos [4 ]
de Noronha, Lorena Aparecida Goncalves [5 ]
Ramalho, Walter Massa [1 ,5 ]
de Araujo, Wildo Navegantes [1 ,5 ,6 ]
Pereira, Alex Leite [1 ,5 ]
Slavov, Svetoslav Nanev [3 ,7 ]
Haddad, Rodrigo [1 ,2 ,5 ,8 ]
机构
[1] Univ Brasilia, Ctr Trop Med, Brasilia, DF, Brazil
[2] Univ Hosp Brasilia, Mol Diagnost Lab, EBSERH, Brasilia, DF, Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Blood Ctr Ribeirao Preto, Ribeirao Preto, SP, Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Genet, Ribeirao Preto, SP, Brazil
[5] Univ Brasilia, Campus Ceilandia, Brasilia, DF, Brazil
[6] Natl Inst Sci & Technol Hlth Technol Assessment, Porto Alegre, RS, Brazil
[7] Butantan Inst, Sao Paulo, Brazil
[8] Ctr Metropolitano DF, Campus Univ, BR-72220275 Brasilia, DF, Brazil
关键词
HPgV-1; Kidney transplant recipients; Genotype; Frequency; GB-VIRUS-C; HEPATITIS-G VIRUS; C/HEPATITIS-G VIRUS; HIGH PREVALENCE; BLOOD-DONORS; INFECTION; HEMODIALYSIS; EPIDEMIOLOGY; DIVERSITY; HIV;
D O I
10.1007/s42770-024-01490-z
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Human Pegivirus Type 1 (HPgV-1), a ubiquitous commensal virus, has been recently suggested as a marker of immunologic function. There is scarce data for the presence, genotypes, and molecular characteristics of HPgV-1 among kidney transplant recipients. Therefore, the objective of this study was to examine the prevalence and the molecular characteristics (cycle threshold, genotypes) of this viral infection among kidney transplant recipients from the Bras & iacute;lia, Federal District of Brazil. HPgV-1 RNA detection in the plasma was assessed by RT-qPCR. Positive samples were submitted to sequencing and phylogenetic analysis of the 5<acute accent>-UTR portion of the viral genome. The estimated HPgV-1 prevalence among renal-transplant recipients was 20%. The performed phylogenetic inference revealed that the most frequent genotype among these patients was HPgV-1 genotype 2 (78.9%) presented by its two subgenotypes (2 A and 2B), followed by genotypes 1 and 3 (10.5% each). This study presents new data about the HPgV-1 circulation and molecular characteristics among kidney transplant recipients from the Federal District of Brazil. Further work is fundamental to examine the effect of HPgV-1 among patients with immunological suppression, including kidney transplant recipients.
引用
收藏
页码:3279 / 3286
页数:8
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