Precise control of transmembrane current via regulating bionic lipid membrane composition

被引：1

作者：

Shang, Zhiwei ^{[1
]}

Zhao, Jing ^{[1
]}

Yang, Mengyu ^{[1
]}

Xiao, Yuling ^{[1
]}

Chu, Wenjing ^{[1
]}

Xu, Shijun ^{[1
]}

Zhang, Xiaojin ^{[1
]}

Yi, Xiaoqing ^{[2
]}

Lin, Meihua ^{[1
]}

Xia, Fan ^{[1
]}

机构：

[1] China Univ Geosci, Fac Mat Sci & Chem, State Key Lab Biogeol & Environm Geol, Engn Res Ctr Nanogeomaterials,Minist Educ, Wuhan 430074, Peoples R China

[2] Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc Cerebrovasc, Minist Educ, Ganzhou, Jiangxi, Peoples R China

来源：

SCIENCE ADVANCES | 2024年 / 10卷 / 35期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

METHYLENE-BLUE; DNA; MOLECULES; SEQUENCE; COMPLEX; BINDING;

D O I：

10.1126/sciadv.adq0118

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The transport of ions through biological ion channels is regulated not only by their structural characteristics but also by the composition of the phospholipid membrane, which serves as a carrier for nanochannels. Inspired by the modulation of ion currents by lipid membrane composition, exemplified by the activation of the K+ channel of Streptomyces A by anionic lipids, we present a biomimetic nanochannel system based on combining DNA nanotechnology with two-dimensional graphene oxide (GO) nanosheets. By designing multibranched DNA nanowires, we assemble programmable DNA scaffold networks (DSNs) on the GO surface to precisely control membrane composition. Modulating the DSN layers from one to five enhances DNA composition, yielding a maximum 12-fold enhancement in ion current, primarily due to charge effects. Incorporating DNAzymes facilitates reversible modulation of membrane composition, enabling cyclic conversion of ion current. This approach offers a pathway for creating devices with highly efficient, tunable ion transport, applicable in diverse fields like mass transport, environmental protection, biomimetic channels, and biosensors.

引用

页数：11

共 47 条

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