AARS Online: A collaborative database on the structure, function, and evolution of the aminoacyl-tRNA synthetases

被引：5

作者：

Douglas, Jordan ^{[1
,2
]}

Cui, Haissi ^{[3
]}

Perona, John J. ^{[4
]}

Vargas-Rodriguez, Oscar ^{[5
]}

Tyynismaa, Henna ^{[6
]}

Carreno, Claudia Alvarez ^{[7
]}

Ling, Jiqiang ^{[8
]}

de Pouplana, Lluis Ribas ^{[9
,10
]}

Yang, Xiang-Lei ^{[11
]}

Ibba, Michael ^{[12
]}

Becker, Hubert ^{[13
]}

Fischer, Frederic ^{[13
]}

Sissler, Marie ^{[13
]}

Carter Jr, Charles W. ^{[14
]}

Wills, Peter R. ^{[1
,2
]}

机构：

[1] Univ Auckland, Dept Phys, Auckland, New Zealand

[2] Univ Auckland, Ctr Computat Evolut, Auckland, New Zealand

[3] Univ Toronto, Dept Chem, Toronto, ON, Canada

[4] Portland State Univ, Dept Chem, Portland, OR USA

[5] Univ Connecticut, Dept Mol Biol & Biophys, Storrs, CT USA

[6] Univ Helsinki, Stem Cells & Metab Res Program, Fac Med, Helsinki, Finland

[7] UCL, Inst Struct & Mol Biol, London, England

[8] Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD USA

[9] Barcelona Inst Sci & Technol, Inst Res Biomed, Barcelona, Catalonia, Spain

[10] Catalan Inst Res & Adv Studies, Barcelona, Catalonia, Spain

[11] Scripps Res Inst, Dept Mol Med, La Jolla, CA USA

[12] Chapman Univ, Biol Sci, Orange, CA USA

[13] Univ Strasbourg, Genet Mol, Genom Microbiol, Strasbourg, France

[14] Univ North Carolina, Dept Biochem & Biophys, Chapel Hill, NC USA

来源：

IUBMB LIFE | 2024年 / 76卷 / 12期

基金：

加拿大健康研究院; 芬兰科学院; 加拿大自然科学与工程研究理事会;

关键词：

aminoacyl-tRNA synthetases; database; protein structure; ASPARAGINYL-TRANSFER-RNA; GLUTAMINYL-TRANSFER-RNA; CRYSTAL-STRUCTURE; GENETIC-CODE; ESCHERICHIA-COLI; ACID ACTIVATION; MISSING LINK; RECOGNITION; BINDING; ORIGIN;

D O I：

10.1002/iub.2911

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aminoacyl-tRNA synthetases (aaRS) are a large group of enzymes that implement the genetic code in all known biological systems. They attach amino acids to their cognate tRNAs, moonlight in various translational and non-translational activities beyond aminoacylation, and are linked to many genetic disorders. The aaRS have a subtle ontology characterized by structural and functional idiosyncrasies that vary from organism to organism, and protein to protein. Across the tree of life, the 22 coded amino acids are handled by 16 evolutionary families of Class I aaRS and 21 families of Class II aaRS. We introduce AARS Online, an interactive Wikipedia-like tool curated by an international consortium of field experts. This platform systematizes existing knowledge about the aaRS by showcasing a taxonomically diverse selection of aaRS sequences and structures. Through its graphical user interface, AARS Online facilitates a seamless exploration between protein sequence and structure, providing a friendly introduction to the material for non-experts and a useful resource for experts. Curated multiple sequence alignments can be extracted for downstream analyses. Accessible at www.aars.online , AARS Online is a free resource to delve into the world of the aaRS.

引用

页码：1091 / 1105

页数：15

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