Exploring the interplay between cannabinoids and thymic functions

被引:0
作者
Lins, Marvin Paulo [1 ,2 ]
de Melo, Igor Santana [3 ]
机构
[1] Univ Fed Mato Grosso, Fac Med, Dept Basic Sci Hlth, Lab Immunol, Cuiaba Campus,Fernando Correa Costa Ave,236, BR-78060900 Cuiaba, MT, Brazil
[2] Fundacao Oswaldo Cruz, Brazilian Natl Inst Sci & Technol Neuroimmunomodul, BR-21040360 Rio De Janeiro, Brazil
[3] Univ Fed Alagoas, Inst Biol & Hlth Sci, Lab Neuropharmacol & Integrat Physiol, BR-57072900 Maceio, Brazil
关键词
Cannabis research; cannabidiol; tetrahydrocannabinol; thymus; thymocyte; KAPPA-B; ORAL DELTA(9)-TETRAHYDROCANNABINOL; CELL DEVELOPMENT; IMMUNE-SYSTEM; CB1; RECEPTORS; CANNABIDIOL; DELTA-9-TETRAHYDROCANNABINOL; THC; PHARMACOLOGY; MARIJUANA;
D O I
10.1093/toxsci/kfae114
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Cannabinoids, derived from the Cannabis sativa plant, have garnered increasing attention for their potential therapeutic applications in various diseases. The pharmacologically active compounds in Cannabis, such as delta-9-tetrahydrocannabinol and cannabidiol, exhibit diverse immunomodulatory properties. Although studies have explored the effects of cannabinoids on immune function, their specific interactions with the thymus, a primary immune organ critical for T-cell development and maturation, remain an intriguing area of investigation. As the thymus plays a fundamental role in shaping the immune repertoire, understanding the interplay between cannabinoids and thymic function may shed light on potential benefits or concerns associated with Cannabis-based therapies. This article aims to provide an overview of the current scientific knowledge regarding the impact of medicinal Cannabis on the thymus and its implications for disease treatment and immune health.
引用
收藏
页码:1 / 12
页数:12
相关论文
共 112 条
[81]   Targeting Cannabinoid Signaling in the Immune System: "High"-ly Exciting Questions, Possibilities, and Challenges [J].
Olah, Attila ;
Szekanecz, Zoltan ;
Biro, Tamas .
FRONTIERS IN IMMUNOLOGY, 2017, 8
[82]   Effect of cannabidiol on endocannabinoid, glutamatergic and GABAergic signalling markers in male offspring of a maternal immune activation (poly I:C) model relevant to schizophrenia [J].
Osborne, Ashleigh L. ;
Solowij, Nadia ;
Babic, Ilijana ;
Lum, Jeremy S. ;
Newell, Kelly A. ;
Huang, Xu-Feng ;
Weston-Green, Katrina .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2019, 95
[83]   Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity [J].
Osei-Hyiaman, D ;
DePetrillo, M ;
Pacher, P ;
Liu, J ;
Radaeva, S ;
Bátkai, S ;
Harvey-White, J ;
Mackie, K ;
Offertáler, L ;
Wang, L ;
Kunos, G .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (05) :1298-1305
[84]   Cannabinoid pharmacology: the first 66 years [J].
Pertwee, RG .
BRITISH JOURNAL OF PHARMACOLOGY, 2006, 147 :S163-S171
[85]   TOLERANCE TO EFFECT OF DELTA1-TETRAHYDROCANNABINOL ON CORTICOSTERONE LEVELS IN MOUSE PLASMA PRODUCED BY REPEATED ADMINISTRATION OF CANNABIS EXTRACT OF DELTA1-TETRAHYDROCANNABINOL [J].
PERTWEE, RG .
BRITISH JOURNAL OF PHARMACOLOGY, 1974, 51 (03) :391-397
[86]   DIFFERENTIAL-EFFECTS OF MARIJUANA COMPONENTS ON PROLIFERATION OF SPLEEN, LYMPH-NODE AND THYMUS-CELLS INVITRO [J].
PROSS, S ;
KLEIN, T ;
NEWTON, C ;
FRIEDMAN, H .
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1987, 9 (03) :363-370
[87]   Network meta-analysis of the molecular mechanisms and signaling pathways underlying alcohol-induced thymic atrophy [J].
Rengifo, Tatiana ;
Bishir, Muhammed ;
Huang, Wenfei ;
Snyder, Marylynn ;
Chang, Sulie L. .
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH, 2024, 48 (05) :795-809
[88]   Constituents of Cannabis Sativa [J].
Rock, Erin M. ;
Parker, Linda A. .
CANNABINOIDS AND NEUROPSYCHIATRIC DISORDERS, 2021, 1264 :1-13
[89]   Transplanted human thymus slices induce and support T-cell development in mice after cryopreservation [J].
Ross, Susan ;
Cheung, Melissa ;
Lau, Ching-In ;
Sebire, Neil ;
Burch, Michael ;
Kilbride, Peter ;
Fuller, Barry ;
Morris, G. John ;
Davies, E. Graham ;
Crompton, Tessa .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2018, 48 (04) :716-719
[90]   Cannabinoid receptor 2 plays a pro-tumorigenic role in non-small cell lung cancer by limiting anti-tumor activity of CD8+ T and NK cells [J].
Sarsembayeva, Arailym ;
Kienzl, Melanie ;
Gruden, Eva ;
Ristic, Dusica ;
Maitz, Kathrin ;
Valadez-Cosmes, Paulina ;
Santiso, Ana ;
Hasenoehrl, Carina ;
Brcic, Luka ;
Lindenmann, Joerg ;
Kargl, Julia ;
Schicho, Rudolf .
FRONTIERS IN IMMUNOLOGY, 2023, 13