Factors Associated with the Development of Depression and the Influence of Obesity on Depressive Disorders: A Narrative Review

被引：9

作者：

Alberti, Adriano ^{[1
,2
]}

Araujo Coelho, David Richer ^{[3
]}

Vieira, Willians Fernando ^{[4
,5
,6
]}

Moehlecke Iser, Betine ^{[7
]}

Lampert, Rose Meiry Fernandez ^{[1
]}

Traebert, Eliane ^{[1
]}

da Silva, Bruna Becker ^{[1
]}

de Oliveira, Bruna Hoffmann ^{[1
]}

Leao, Graziela Marques ^{[1
]}

Souza, Gabriela de ^{[1
]}

Dallacosta, Fabiana Meneghetti ^{[8
]}

Kades, Gabriela ^{[8
]}

Madeira, Kristian ^{[9
]}

Chupel, Matheus Uba ^{[10
]}

Grossl, Fernando Schorr ^{[8
]}

Souza, Renan ^{[8
]}

Hur Soares, Ben ^{[11
]}

da Rocha, Ricelli Endrigo Ruppel ^{[12
]}

Sipriano, Erica da Silva ^{[9
]}

Martins, Daniel Fernandes ^{[1
]}

Agostinetto, Lenita ^{[2
]}

机构：

[1] Univ Southern St Catarina UNISUL, Dept Biol, Hlth Sci Program Hlth Sci, BR-88132260 Palhoca, Brazil

[2] Univ Planalto Catarinense UNIPLAC, Grad Program Environm & Hlth, BR-88509900 Lages, Brazil

[3] Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA

[4] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo, SP, Brazil

[5] Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, Brazil

[6] Fac Sao Leopoldo Mand, Lab Neuroimmune Interface Pain Res, Inst Sao Leopoldo Mand, BR-13045755 Campinas, Brazil

[7] Univ Southern Santa Catarina UNISUL, Dept Biol, Hlth Sci Posgrad Program Hlth Sci, BR-88704900 Tubarao, Brazil

[8] Univ West Santa Catarina, Dept Biosci & Hlth, BR-89600000 Joacaba, Brazil

[9] Univ Extreme South Santa Catarina UNESC, Dept Math & Hlth Sci, BR-88806000 Criciuma, Brazil

[10] Sunnybrook Res Inst, Hurvitz Brain Sci, Biol Sci Platform, Toronto, ON M4N 3M5, Canada

[11] Univ Passo Fundo, Dept Phys Educ & Physiotherapy, BR-99052900 Passo Fundo, Brazil

[12] Univ Alto Vale Rio do Peixe, Dept Grad Program Dev, Soc PPGEDS UNIARP, BR-89500199 Cacador, Brazil

来源：

BIOMEDICINES | 2024年 / 12卷 / 09期

基金：

巴西圣保罗研究基金会;

关键词：

obesity; depression; mental health; inflammation; ADVERSE CHILDHOOD EXPERIENCES; CORONARY-ARTERY-DISEASE; PHYSICAL-ACTIVITY; MAJOR DEPRESSION; VEGETABLE CONSUMPTION; DIETARY PATTERNS; MOOD DISORDERS; IMMUNE-SYSTEM; RISK-FACTOR; INFLAMMATION;

D O I：

10.3390/biomedicines12091994

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Depression affects several aspects of life, including socioeconomic status, relationships, behavior, emotions, and overall health. The etiology of depression is complex and influenced by various factors, with obesity emerging as a significant contributor. This narrative review aims to investigate the factors associated with the development of depression, with a particular focus on the role of obesity. The literature search was conducted on PubMed, Embase, and PsycINFO from May to July 2024. The review highlights the impact of environmental and socioeconomic conditions; lifestyle choices, including physical activity and dietary habits; stress; traumatic experiences; neurotransmitter imbalances; medical and psychological conditions; hormone fluctuations; and epigenetic factors on depression. A key emphasis is placed on the inflammatory processes linked to obesity, which may drive the bidirectional relationship between obesity and depression. The findings suggest that obesity is associated with an increased risk of depression, potentially due to chronic inflammation, neurochemical dysregulation, and the emotional and social challenges related to weight stigma and obesity management. Understanding these interconnected factors is important for developing targeted interventions to address both obesity and depression, leading to improved quality of life for those affected.

引用

页数：27

共 212 条

[31]

Centers for Disease Control and Prevention (CDC), Substance Use

[32]

Chu Andrew., 2024, StatPearls

[33] Microbiota Implications in Endocrine-Related Diseases: From Development to Novel Therapeutic Approaches [J].

Clemente-Suarez, Vicente Javier ;

Redondo-Florez, Laura ;

Rubio-Zarapuz, Alejandro ;

Martin-Rodriguez, Alexandra ;

Tornero-Aguilera, Jose Francisco .

BIOMEDICINES, 2024, 12 (01)

[34] Treating neuropathic pain and comorbid affective disorders: Preclinical and clinical evidence [J].

Coelho, David Richer Araujo ;

Gersten, Maia ;

Jimenez, Alma Sanchez ;

Fregni, Felipe ;

Cassano, Paolo ;

Vieira, Willians Fernando .

PAIN PRACTICE, 2024, 24 (07) :937-955

[35] Inflammation in obsessive-compulsive disorder: A literature review and hypothesis-based potential of transcranial photobiomodulation [J].

Coelho, David Richer Araujo ;

Salvi, Joshua D. ;

Vieira, Willians Fernando ;

Cassano, Paolo .

JOURNAL OF NEUROSCIENCE RESEARCH, 2024, 102 (03)

[36] Environmental factors linked to depression vulnerability are associated with altered cerebellar resting-state synchronization [J].

Cordova-Palomera, Aldo ;

Tornador, Cristian ;

Falcon, Carles ;

Bargallo, Nuria ;

Brambilla, Paolo ;

Crespo-Facorro, Benedicto ;

Deco, Gustavo ;

Fananas, Lourdes .

SCIENTIFIC REPORTS, 2016, 6

[37]

Cuche H., 1994, No Aguento Mais: Um Guia para Compreender e Combater a Depresso, V2nd ed.

[38] Diet, Gut Microbiota, and Obesity: Links with Host Genetics and Epigenetics and Potential Applications [J].

Cuevas-Sierra, Amanda ;

Ramos-Lopez, Omar ;

Riezu-Boj, Jose I. ;

Milagro, Fermin I. ;

Alfredo Martinez, J. .

ADVANCES IN NUTRITION, 2019, 10 :S17-S30

[39] Major depressive disorder: hypothesis, mechanism, prevention and treatment [J].

Cui, Lulu ;

Li, Shu ;

Wang, Siman ;

Wu, Xiafang ;

Liu, Yingyu ;

Yu, Weiyang ;

Wang, Yijun ;

Tang, Yong ;

Xia, Maosheng ;

Li, Baoman .

SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 9 (01)

[40] Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder [J].

Cutler, Andrew J. ;

Mattingly, Gregory W. ;

Maletic, Vladimir .

TRANSLATIONAL PSYCHIATRY, 2023, 13 (01)

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