The role of liquid-liquid phase separation in defining cancer EMT

被引：3

作者：

Li, Yuan ^{[1
,2
]}

Feng, Yuqing ^{[2
,3
]}

Geng, Songmei ^{[3
]}

Xu, Feng ^{[1
,2
]}

Guo, Hui ^{[4
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Life Sci & Technol, MOE Key Lab Biomed Informat Engn, Xian 710049, Peoples R China

[2] Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr BEBC, Xian 710049, Peoples R China

[3] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Dermatol, Xian 710004, Peoples R China

[4] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Med Oncol, Xian 710004, Shaanxi, Peoples R China

来源：

LIFE SCIENCES | 2024年 / 353卷

基金：

中国国家自然科学基金;

关键词：

EMT; Liquid-liquid phase separation; Cancer; Mechanobiology; EPITHELIAL-MESENCHYMAL TRANSITION; PROGRESSION; BODIES; NEAT1; GENES; AXIS; FUS;

D O I：

10.1016/j.lfs.2024.122931

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cancer EMT is a pivotal process that drives carcinogenesis, metastasis, and cancer recurrence, with its initiation and regulation intricately governed by biochemical pathways in a precise spatiotemporal manner. Recently, the membrane-less biomolecular condensates formed via liquid-liquid phase separation (LLPS) have emerged as a universal mechanism underlying the spatiotemporal collaboration of biological activities in cancer EMT. In this review, we first elucidate the current understanding of LLPS formation and its cellular functions, followed by an overview of valuable tools for investigating LLPS. Secondly, we examine in detail the LLPS-mediated biological processes crucial for the initiation and regulation of cancer EMT. Lastly, we address current challenges in advancing LLPS research and explore the potential modulation of LLPS using therapeutic agents.

引用

页数：12

共 121 条

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