Self-Assembled Ferritin Nanoparticles for Delivery of Antigens and Development of Vaccines: From Structure and Property to Applications

被引:9
作者
Cao, Shinuo [1 ]
Ma, Dongxue [2 ]
Ji, Shengwei [2 ]
Zhou, Mo [1 ]
Zhu, Shanyuan [1 ]
机构
[1] Jiangsu Agrianim Husb Vocat Coll, Engn Technol Res Ctr Modern Anim Sci & Novel Vet P, Jiangsu Key Lab High Tech Res & Dev Vet Biopharmac, Taizhou 225306, Peoples R China
[2] Yanbian Univ, Agr Coll, Dept Vet Med, Yanji 133000, Jilin, Peoples R China
关键词
ferritin; self-assembled protein; nanoparticles; vaccines; DNA-BINDING PROTEIN; VIRUS-LIKE PARTICLES; IRON STORAGE; CRYSTAL-STRUCTURE; H-CHAIN; DPS; OVEREXPRESSION; MANIPULATIONS; PROTECTION; MECHANISM;
D O I
10.3390/molecules29174221
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ferritin, an iron storage protein, is ubiquitously distributed across diverse life forms, fulfilling crucial roles encompassing iron retention, conversion, orchestration of cellular iron metabolism, and safeguarding cells against oxidative harm. Noteworthy attributes of ferritin include its innate amenability to facile modification, scalable mass production, as well as exceptional stability and safety. In addition, ferritin boasts unique physicochemical properties, including pH responsiveness, resilience to elevated temperatures, and resistance to a myriad of denaturing agents. Therefore, ferritin serves as the substrate for creating nanomaterials typified by uniform particle dimensions and exceptional biocompatibility. Comprising 24 subunits, each ferritin nanocage demonstrates self-assembly capabilities, culminating in the formation of nanostructures akin to intricate cages. Recent years have witnessed the ascendance of ferritin-based self-assembled nanoparticles, owing to their distinctive physicochemical traits, which confer substantial advantages and wide-ranging applications within the biomedical domain. Ferritin is highly appealing as a carrier for delivering drug molecules and antigen proteins due to its distinctive structural and biochemical properties. This review aims to highlight recent advances in the use of self-assembled ferritin as a novel carrier for antigen delivery and vaccine development, discussing the molecular mechanisms underlying its action, and presenting it as a promising and effective strategy for the future of vaccine development.
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页数:22
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