T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

被引:557
作者
Crespo, Joel [1 ,2 ,3 ]
Sun, Haoyu [4 ]
Welling, Theodore H. [1 ]
Tian, Zhigang [4 ]
Zou, Weiping [1 ,2 ,3 ]
机构
[1] Dept Surg, Ann Arbor, MI USA
[2] Grad Program Immunol & Tumor Biol, Ann Arbor, MI USA
[3] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
[4] Univ Sci & Technol China, Inst Immunol, Sch Life Sci, Hefei 230026, Peoples R China
关键词
CHRONIC VIRAL-INFECTION; E3 UBIQUITIN LIGASE; GENE-TRANSCRIPTION; ANTITUMOR IMMUNITY; LYMPHOCYTE-T; REPLICATIVE SENESCENCE; INHIBITORY RECEPTORS; MOLECULAR SIGNATURE; MELANOMA PATIENTS; UP-REGULATION;
D O I
10.1016/j.coi.2012.12.003
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human tumors progress despite the presence of tumor associated antigen (TAA)-specific T cells. Many different molecular and cellular mechanisms contribute to the failure of T cells to eradicate the tumor. These include immune suppressive networks that impair ongoing T cell function and enable tumor escape. Recent studies have started to reveal the nature of effector T cells in the tumor microenvironment. In this article we discuss T cell anergy, exhaustion, senescence, and sternness, and review the phenotype of dysfunctional T cell subsets and the underlying molecular mechanisms in the tumor microenvironments. We suggest that targeting T cell dysfunctional mechanisms and introducing/promoting T cell sternness are important approaches to treat patients with cancer.
引用
收藏
页码:214 / 221
页数:8
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