共 76 条
T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
被引:557
作者:

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Sun, Haoyu
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机构:
Univ Sci & Technol China, Inst Immunol, Sch Life Sci, Hefei 230026, Peoples R China Dept Surg, Ann Arbor, MI USA

Welling, Theodore H.
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机构:
Dept Surg, Ann Arbor, MI USA Dept Surg, Ann Arbor, MI USA

Tian, Zhigang
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机构:
Univ Sci & Technol China, Inst Immunol, Sch Life Sci, Hefei 230026, Peoples R China Dept Surg, Ann Arbor, MI USA

Zou, Weiping
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机构:
Dept Surg, Ann Arbor, MI USA
Grad Program Immunol & Tumor Biol, Ann Arbor, MI USA
Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA Dept Surg, Ann Arbor, MI USA
机构:
[1] Dept Surg, Ann Arbor, MI USA
[2] Grad Program Immunol & Tumor Biol, Ann Arbor, MI USA
[3] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
[4] Univ Sci & Technol China, Inst Immunol, Sch Life Sci, Hefei 230026, Peoples R China
关键词:
CHRONIC VIRAL-INFECTION;
E3 UBIQUITIN LIGASE;
GENE-TRANSCRIPTION;
ANTITUMOR IMMUNITY;
LYMPHOCYTE-T;
REPLICATIVE SENESCENCE;
INHIBITORY RECEPTORS;
MOLECULAR SIGNATURE;
MELANOMA PATIENTS;
UP-REGULATION;
D O I:
10.1016/j.coi.2012.12.003
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Human tumors progress despite the presence of tumor associated antigen (TAA)-specific T cells. Many different molecular and cellular mechanisms contribute to the failure of T cells to eradicate the tumor. These include immune suppressive networks that impair ongoing T cell function and enable tumor escape. Recent studies have started to reveal the nature of effector T cells in the tumor microenvironment. In this article we discuss T cell anergy, exhaustion, senescence, and sternness, and review the phenotype of dysfunctional T cell subsets and the underlying molecular mechanisms in the tumor microenvironments. We suggest that targeting T cell dysfunctional mechanisms and introducing/promoting T cell sternness are important approaches to treat patients with cancer.
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页码:214 / 221
页数:8
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