Hypervalent Iodine-Mediated C3-Trifluoropropionyloxylation of N-Substituted Indoles

被引：0

作者：

Tian, Yao ^{[1
]}

Zhou, Ming-Xi ^{[2
]}

Wang, Yue ^{[2
]}

Zeng, Zi-Pei ^{[2
]}

Guo, Yu ^{[2
]}

Zhong, Yuan ^{[3
]}

Zeng, Yao-Fu ^{[2
]}

机构：

[1] Hunan Vocat Coll Sci & Technol, Coll Pharm, Changsha 410004, Hunan, Peoples R China

[2] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China

[3] Guhan Tradit Chinese Med Co Ltd, Hengyang 421001, Hunan, Peoples R China

来源：

CHEMISTRYSELECT | 2024年 / 9卷 / 37期

关键词：

Indole; Metal-free; Trifluoropropionyloxylation; CHEMISTRY;

D O I：

10.1002/slct.202403780

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A metal-free hypervalent iodine-mediated C3-trifluoropropionyloxylation of N-substituted indoles was developed. (Bis-trifluoropropanoate)iodobenzene was used as both the oxidant and fluorine source. The reaction was sensitive to the N-protecting groups of the indoles. N-acylated indoles provided 3-trifluoropropionyloxylated indoles, while 3-trifluoropropionyloxylated oxindoles were generated from indoles bearing N-alkyl groups.

引用

页数：7

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