Retrospect, advances and challenges in Chagas disease diagnosis: a comprehensive review

被引:20
作者
Schijman, Alejandro Gabriel [1 ,6 ]
Alonso-Padilla, Julio [2 ,5 ]
Britto, Constanca [3 ]
Bernal, Claudia Patricia Herrera [4 ]
机构
[1] INGEBI CONICET, Lab Biol Mol Enfermedad Chagas, Inst Invest Ingn Genet & Biol Mol Dr Hector Torres, Vuelta de Obligado 2490, RA-1428 Buenos Aires, Adn, Argentina
[2] Univ Barcelona, Hosp Clin, Barcelona Inst Global Hlth ISGlobal, Carrer Rossello 149, Barcelona 08036, Spain
[3] Fiocruz MS, Fundacao Oswaldo Cruz, Lab Mol Biol & Endem Dis, Inst Oswaldo Cruz, Ave Brasil 4365, BR-21045900 Manguinho, RJ, Brazil
[4] Tulane Univ, Sch Publ Hlth & Trop Med, 1440 Canal St, New Orleans, LA 70112 USA
[5] CIBER Enfermedades Infecciosas CIBERINFEC, Madrid, Spain
[6] Vuelta de Obligado 2490, RA-1438 Buenos Aires, Adn, Argentina
来源
LANCET REGIONAL HEALTH-AMERICAS | 2024年 / 36卷
关键词
Chagas disease; Diagnosis; Surveillance; Point-of-care; Isothermal ampli fi cation; Rapid diagnostic tests; DISCRETE TYPING UNITS; TRYPANOSOMA-CRUZI; FOLLOW-UP; BLOOD; AMPLIFICATION; REACTIVATION; INFECTION; EFFICACY; REGIONS; ASSAY;
D O I
10.1016/j.lana.2024.100821
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Chagas disease, caused by Trypanosoma cruzi , affects millions worldwide. The 2030 WHO roadmap aims to eliminate it as a public health concern, emphasising the need for timely diagnosis to enhance treatment access. Current diagnostic algorithms, which rely on multiple tests, have prolonged turnaround times. This proves particularly problematic in resource -limited settings. Addressing this issue necessitates the validation and adoption of innovative tools. We explore recent developments in Chagas disease diagnosis, reviewing historical context and advancements. Despite progress, challenges persist. This article contributes to the understanding of current and future directions in this neglected healthcare area. Parasitological methods are simple but exhibit low sensitivity and require supplementary tests. Molecular methods, with automation potential, allow quanti fi cation and higher throughput. Serological tools show good performance but struggle with parasite antigenic diversity. Prioritising point -of -care tests is crucial for widespread accessibility and could offer a strategy to control disease impact. Ultimately, balancing achievements and ongoing obstacles is essential for comprehensive progress.
引用
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页数:14
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