CAR T cell therapy for pediatric central nervous system tumors: a review of the literature and current North American trials

被引:1
作者
Ronsley, Rebecca [1 ,2 ]
Bertrand, Kelsey C. [3 ,4 ]
Song, Edward Z. [2 ]
Timpanaro, Andrea [2 ]
Choe, Michelle [1 ,5 ]
Tlais, Dana [3 ,4 ]
Vitanza, Nicholas A. [1 ,2 ]
Park, Julie R. [3 ]
机构
[1] Univ Washington, Seattle Childrens Hosp, Dept Pediat, Seattle, WA USA
[2] Seattle Childrens Res Inst, Ben Towne Ctr Childhood Canc Res, Seattle, WA USA
[3] St Jude Childrens Res Hosp, Dept Oncol, 262 Danny Thomas Pl, Memphis, TN 38105 USA
[4] St Jude Childrens Res Hosp, Dept Oncol, Div Neurooncol, Memphis, TN USA
[5] Fred Hutchinson Canc Ctr, Clin Res Div, Seattle, WA USA
关键词
Chimeric antigen receptor; Central nervous system; Pediatric; Cancer; Immunotherapy; CHIMERIC ANTIGEN RECEPTOR; CYTOKINE RELEASE SYNDROME; GLIOBLASTOMA; REGRESSION; EXPRESSION; TARGET; EPHA2; B7-H3; IDENTIFICATION; IMMUNOTHERAPY;
D O I
10.1007/s10555-024-10208-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Central nervous system (CNS) tumors are the leading cause of cancer-related death in children. Typical therapy for CNS tumors in children involves a combination of surgery, radiation, and chemotherapy. While upfront therapy is effective for many high-grade tumors, therapy at the time of relapse remains limited. Furthermore, for diffuse intrinsic pontine glioma (DIPG) and diffuse midline glioma (DMG), there are currently no curative therapies. Chimeric antigen receptor T (CAR T) cell therapy is a promising novel treatment avenue for these tumors. Here, we review the preclinical evidence for CAR T cell use in pediatric brain tumors, the preliminary clinical experience of CNS CAR T cell trials, toxicity associated with systemic and locoregional CAR T cell therapy for CNS tumors, challenges in disease response evaluation with CAR T cell therapy, and the knowledge gained from correlative biologic studies from these trials in the pediatric and young adult population.
引用
收藏
页码:1205 / 1216
页数:12
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