MAFLD-related hepatocellular carcinoma: Exploring the potent combination of immunotherapy and molecular targeted therapy

被引：1

作者：

Guo, Ziwei ^{[1
]}

Yao, Ziang ^{[2
]}

Huang, Bohao ^{[3
]}

Wu, Dongjie ^{[1
]}

Li, Yanbo ^{[1
]}

Chen, Xiaohan ^{[5
]}

Lu, Yanping ^{[4
]}

Wang, Li ^{[1
]}

Lv, Wenliang ^{[1
]}

机构：

[1] Guanganmen Hosp, China Acad Chinese Med Sci, Dept Infect, Beijing 100053, Peoples R China

[2] Peking Univ, Peoples Hosp, Dept Tradit Chinese Med, Beijing 100044, Peoples R China

[3] Beijing Univ Chinese Med, Beijing 100105, Peoples R China

[4] Guangzhou Univ Chinese Med, Shenzhen Baoan Chinese Med Hosp, Dept Hepatol, Shenzhen 518100, Peoples R China

[5] Guanganmen Hosp, China Acad Chinese Med Sci, Dept Hematol, Beijing 100053, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2024年 / 140卷

关键词：

Metabolic dysfunction-associated fatty liver; disease; MAFLD-HCC; Immunotherapy; Immune checkpoint inhibitors; Molecular targeted therapy; FATTY LIVER-DISEASE; NF-KAPPA-B; REGULATORY T-CELLS; NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE; SIGNALING PATHWAYS; HIPPO PATHWAY; NAFLD; NASH; HCC;

D O I：

10.1016/j.intimp.2024.112821

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hepatocellular carcinoma (HCC) is a common cause of cancer-related mortality and morbidity globally, and with the prevalence of metabolic-related diseases, the incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) related hepatocellular carcinoma (MAFLD-HCC) continues to rise with the limited efficacy of conventional treatments, which has created a major challenge for HCC surveillance. Immune checkpoint inhibitors (ICIs) and molecularly targeted drugs offer new hope for advanced MAFLD-HCC, but the evidence for the use of both types of therapy in this type of tumour is still insufficient. Theoretically, the combination of immunotherapy, which awakens the body's anti-tumour immunity, and targeted therapies, which directly block key molecular events driving malignant progression in HCC, is expected to produce synergistic effects. In this review, we will discuss the progress of immunotherapy and molecular targeted therapy in MAFLD-HCC and look forward to the opportunities and challenges of the combination therapy.

引用

页数：14

共 231 条

[11] Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy [J].

Arroyave-Ospina, Johanna C. ;

Wu, Zongmei ;

Geng, Yana ;

Moshage, Han .

ANTIOXIDANTS, 2021, 10 (02) :1-25

[12] Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma [J].

Behary, Jason ;

Amorim, Nadia ;

Jiang, Xiao-Tao ;

Raposo, Anita ;

Gong, Lan ;

McGovern, Emily ;

Ibrahim, Ragy ;

Chu, Francis ;

Stephens, Carlie ;

Jebeili, Hazem ;

Fragomeli, Vincenzo ;

Koay, Yen Chin ;

Jackson, Miriam ;

O'Sullivan, John ;

Weltman, Martin ;

McCaughan, Geoffrey ;

El-Omar, Emad ;

Zekry, Amany .

NATURE COMMUNICATIONS, 2021, 12 (01)

[13] Liver dendritic cells and NAFLD evolution: A remaining open issue [J].

Bernsmeier, Christine ;

Albano, Emanuele .

JOURNAL OF HEPATOLOGY, 2017, 66 (06) :1120-1122

[14] Molecular pathways of nonalcoholic fatty liver disease development and progression [J].

Bessone, Fernando ;

Valeria Razori, Maria ;

Roma, Marcelo G. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2019, 76 (01) :99-128

[15] Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis [J].

Bhattacharya, Dipankar ;

Basta, Brittany ;

Mato, Jose M. ;

Craig, Amanda ;

Fernandez-Ramos, David ;

Lopitz-Otsoa, Fernando ;

Tsvirkun, Darya ;

Hayardeny, Liat ;

Chandar, Vasuretha ;

Schwartz, Robert E. ;

Villanueva, Augusto ;

Friedman, Scott L. .

JHEP REPORTS, 2021, 3 (03)

[16] New avenues for NASH therapy by targeting ACC [J].

Bian, Huijie ;

Liu, Ye-Mao ;

Chen, Zhi-Nan .

CELL METABOLISM, 2022, 34 (02) :191-193

[17] The mechanisms of Hedgehog signalling and its roles in development and disease [J].

Briscoe, James ;

Therond, Pascal P. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2013, 14 (07) :416-429

[18] The effect of liver disease on hepatic microenvironment and implications for immune therapy [J].

Brown, Zachary J. ;

Ruff, Samantha M. ;

Pawlik, Timothy M. .

FRONTIERS IN PHARMACOLOGY, 2023, 14

[19] Management of Hepatocellular Carcinoma A Review [J].

Brown, Zachary J. ;

Tsilimigras, Diamantis I. ;

Ruff, Samantha M. ;

Mohseni, Alireza ;

Kamel, Ihab R. ;

Cloyd, Jordan M. ;

Pawlik, Timothy M. .

JAMA SURGERY, 2023, 158 (04) :410-420

[20] PTEN suppresses tumorigenesis by directly dephosphorylating Akt [J].

Bu, Lang ;

Wang, Huan ;

Pan, Ji-an ;

Chen, Lang ;

Xing, Fan ;

Wu, Junyu ;

Li, Shun ;

Guo, Deyin .

SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 6 (01)

← 1 2 3 4 5 6 7 8 9 10 →