Association of DNA methylation, polymorphism and mRNA level of ALAS1 with antituberculosis drug-induced liver injury

被引：0
|
作者：
Hao, Zhuolu [1 ]
Han, Bing [1 ]
Zhou, Xinyue [1 ]
Jian, Hongkai [2 ]
He, Xiaomin [3 ]
Lu, Lihuan [4 ]
Zhang, Meiling [5 ]
Pan, Hongqiu [6 ]
Yi, Honggang [1 ]
Tang, Shaowen [1 ]
机构：
[1] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing 211166, Peoples R China
[2] Nanjing Med Univ, Dept Internal Med, Clin Med Coll 1, Nanjing 211166, Peoples R China
[3] Peoples Hosp Taixing, Dept Infect Dis, Taixing 225400, Peoples R China
[4] Second Peoples Hosp Changshu, Dept TB, Changshu 215500, Peoples R China
[5] Jiangsu Univ, Jurong Hosp, Dept Infect Dis, Jurong 212400, Peoples R China
[6] Jiangsu Univ, Peoples Hosp Zhenjiang 3, Dept TB, Zhenjiang 212021, Peoples R China
来源：
PHARMACOGENOMICS | 2024年 / 25卷 / 10-11期
基金：
中国国家自然科学基金;
关键词：
ALAS1; AT-DILI; DNA methylation; SNP; synergistic effect; HEPATOTOXICITY; RIFAMPICIN;
D O I：
10.1080/14622416.2024.2392480
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: To investigate the association of DNA methylation, genetic polymorphisms and mRNA level of aminolevulinate synthase 1 (ALAS1) with antituberculosis drug-induced liver injury (AT-DILI) risk. Methods: Based on a 1:1 matched case-control study with 182 cases and 182 controls, one CpG island and three single nucleotide polymorphisms (SNPs) were detected. ALAS1 mRNA level was detected in 34 samples. Results: Patients with methylation status were at high risk of AT-DILI (odds ratio: 1.567, 95% CI: 1.015-2.421, p = 0.043) and SNP rs352169 was associated with AT-DILI risk (GA vs. GG, odds ratio: 1.770, 95% CI: 1.101-2.847, p = 0.019). ALAS1 mRNA level in the cases was significantly lower than that in the controls (0.75 +/- 0.34 vs. 1.00 +/- 0.42, p = 0.021). Conclusion: The methylation status and SNP rs352169 of ALAS1 were associated with AT-DILI risk.
引用
收藏
页码：451 / 460
页数：10
相关论文
共 50 条
  • [21] Utility of Liver Biopsy in the Diagnosis and Management of Possible Drug-Induced Liver Injury in Patients Receiving Antituberculosis Therapy: A Retrospective Study
    Gualano, Gina
    Zace, Drieda
    Mosti, Silvia
    Mencarini, Paola
    Musso, Maria
    Libertone, Raffaella
    Cerva, Carlotta
    Goletti, Delia
    Rianda, Alessia
    Del Nonno, Franca
    Falasca, Laura
    Palmieri, Fabrizio
    INFECTIOUS DISEASE REPORTS, 2023, 15 (06) : 735 - 746
  • [22] DNA Methylation of the CYP1A1 Promoter Region is Associated with Anti-tuberculous Drug-induced Hepatic Injury
    Ren, Qi
    Sun, Shufeng
    Niu, Chen
    Li, Yuhong
    Chong, Yingzhi
    Li, Biao
    Zheng, Guoying
    Feng, Fumin
    PAKISTAN JOURNAL OF ZOOLOGY, 2020, 52 (01) : 293 - 301
  • [23] TANC1 methylation as a novel biomarker for the diagnosis of patients with anti-tuberculosis drug-induced liver injury
    Wu, Dongxue
    Li, Yuhong
    Ren, Qi
    Pei, Shengfei
    Wang, Lin
    Yang, Luming
    Chong, Yingzhi
    Sun, Shufeng
    Hao, Jinqi
    Feng, Fumin
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [24] Drug-induced liver injury after covid-19 mRNA vaccine: case report
    Rivera-Tenorio, Ayleen
    Hernandez Diaz, Hector
    Andres Triana, Pablo
    Gutierrez-Posso, Juliana
    Maria Osorio-Gomez, Ana
    Ernesto Saez Velandia, Julio
    Salazar Acosta, William
    Dario Portillo-Mino, Jose
    COLOMBIA MEDICA, 2022, 53 (03):
  • [25] Chronic hepatitis B infection and risk of antituberculosis drug-induced liver injury: Systematic review and meta-analysis
    Wang, Ning-Tao
    Huang, Yi-Shin
    Lin, Meng-Hsien
    Huang, Bryan
    Perng, Chin-Lin
    Lin, Han-Chieh
    JOURNAL OF THE CHINESE MEDICAL ASSOCIATION, 2016, 79 (07) : 368 - 374
  • [26] Roles of NR1I3 and NR1H4 polymorphisms in the susceptibility to antituberculosis drug-induced liver injury in China: a case-control study
    Xu, Xiaoyan
    Chen, Ruina
    Lu, Lihuan
    Cheng, Jingru
    He, Xiaomin
    Pan, Hongqiu
    Zhang, Meiling
    Yi, Honggang
    Tang, Shaowen
    FRONTIERS IN GENETICS, 2024, 15
  • [27] Research advances in the association of drug-induced liver injury with polymorphisms in human leukocyte antigen
    Ma, Qingmei
    Yang, Wenjuan
    Wang, Lu
    Ma, Li
    Jing, Yanmei
    Wang, Jiamei
    Liu, Xinyue
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2020, 81
  • [28] Drug-induced liver injury: A management position paper from the Latin American Association for Study of the liver
    Bessone, Fernando
    Hernandez, Nelia
    Tagle, Martin
    Arrese, Marco
    Parana, Raymundo
    Mendez-Sanchez, Nahum
    Ridruejo, Ezequiel
    Mendizabal, Manuel
    Dagher, Lucy
    Contreras, Fernando
    Fassio, Eduardo
    Pessoa, Mario
    Brahm, Javier
    Silva, Marcelo
    ANNALS OF HEPATOLOGY, 2021, 24
  • [29] Prophylactic Therapy of Silymarin (Milk Thistle) on Antituberculosis Drug-Induced Liver Injury: A Meta-Analysis of Randomized Controlled Trials
    Tao, Lina
    Qu, Xiaoyu
    Zhang, Yue
    Song, Yanqing
    Zhang, Si-xi
    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2019, 2019
  • [30] Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis
    Chen, Xinyu
    Hao, Zhuolu
    Wang, Nannan
    Zhu, Jia
    Yi, Honggang
    Tang, Shaowen
    JOURNAL OF TROPICAL MEDICINE, 2023, 2023
12345