Association of DNA methylation, polymorphism and mRNA level of ALAS1 with antituberculosis drug-induced liver injury

被引：0
|
作者：
Hao, Zhuolu [1 ]
Han, Bing [1 ]
Zhou, Xinyue [1 ]
Jian, Hongkai [2 ]
He, Xiaomin [3 ]
Lu, Lihuan [4 ]
Zhang, Meiling [5 ]
Pan, Hongqiu [6 ]
Yi, Honggang [1 ]
Tang, Shaowen [1 ]
机构：
[1] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing 211166, Peoples R China
[2] Nanjing Med Univ, Dept Internal Med, Clin Med Coll 1, Nanjing 211166, Peoples R China
[3] Peoples Hosp Taixing, Dept Infect Dis, Taixing 225400, Peoples R China
[4] Second Peoples Hosp Changshu, Dept TB, Changshu 215500, Peoples R China
[5] Jiangsu Univ, Jurong Hosp, Dept Infect Dis, Jurong 212400, Peoples R China
[6] Jiangsu Univ, Peoples Hosp Zhenjiang 3, Dept TB, Zhenjiang 212021, Peoples R China
来源：
PHARMACOGENOMICS | 2024年 / 25卷 / 10-11期
基金：
中国国家自然科学基金;
关键词：
ALAS1; AT-DILI; DNA methylation; SNP; synergistic effect; HEPATOTOXICITY; RIFAMPICIN;
D O I：
10.1080/14622416.2024.2392480
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: To investigate the association of DNA methylation, genetic polymorphisms and mRNA level of aminolevulinate synthase 1 (ALAS1) with antituberculosis drug-induced liver injury (AT-DILI) risk. Methods: Based on a 1:1 matched case-control study with 182 cases and 182 controls, one CpG island and three single nucleotide polymorphisms (SNPs) were detected. ALAS1 mRNA level was detected in 34 samples. Results: Patients with methylation status were at high risk of AT-DILI (odds ratio: 1.567, 95% CI: 1.015-2.421, p = 0.043) and SNP rs352169 was associated with AT-DILI risk (GA vs. GG, odds ratio: 1.770, 95% CI: 1.101-2.847, p = 0.019). ALAS1 mRNA level in the cases was significantly lower than that in the controls (0.75 +/- 0.34 vs. 1.00 +/- 0.42, p = 0.021). Conclusion: The methylation status and SNP rs352169 of ALAS1 were associated with AT-DILI risk.
引用
收藏
页码：451 / 460
页数：10
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