Unraveling Quercetin's Potential: A Comprehensive Review of Its Properties and Mechanisms of Action, in Diabetes and Obesity Complications

被引：1
作者：
Yi, Ruhan [1 ]
Liu, Yun [1 ]
Zhang, Xu [1 ]
Sun, Xiance [2 ]
Wang, Ningning [1 ]
Zhang, Cong [1 ]
Deng, Haoyuan [1 ]
Yao, Xiaofeng [2 ]
Wang, Shaopeng [3 ]
Yang, Guang [1 ]
机构：
[1] Dalian Med Univ, Dept Food Nutr & Safety, Dalian, Peoples R China
[2] Dalian Med Univ, Dept Occupat & Environm Hlth, Dalian, Peoples R China
[3] Dalian Med Univ, Affiliated Hosp 1, Dept Cardiol, Dalian, Peoples R China
来源：
PHYTOTHERAPY RESEARCH | 2024年 / 38卷 / 12期
基金：
中国国家自然科学基金;
关键词：
hypoglycemic; insulin resistance; quercetin; T2DM; INSULIN-RESISTANCE; OXIDATIVE STRESS; SKELETAL-MUSCLE; GENE-EXPRESSION; INFLAMMATION; LIVER; ACID; RATS; HOMEOSTASIS; METABOLISM;
D O I：
10.1002/ptr.8332
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The prevalence of diabetes is escalating alarmingly, placing a significant economic burden on the global healthcare system. The use of chemical substances extracted from plants has been demonstrated to be an effective method for the treatment and control of insulin resistance and Type 2 diabetes mellitus (T2DM). New research indicates that natural phytochemicals present in fruits and vegetables are expected to become drugs for the treatment of diabetes and the prevention of related complications. Quercetin, a widely distributed flavonoid, is well-known for its antioxidant, anti-inflammatory, anticancer, and antidiabetic properties. This article provides a comprehensive account of the mechanism of action of quercetin on diabetes and obesity complications in vivo and in vitro. It elucidates the impact of quercetin on various cells. These include hepatocytes, renal cells, skeletal muscle cells, and adipocytes. Furthermore, this article discusses the mechanism of quercetin on organ damage in diabetic mice induced by STZ, alloxan, diet, and spontaneous Type 2 diabetic mice caused by genetic defects. Additionally, it addresses the pharmacokinetics of quercetin and its potential for synergistic effects with existing diabetic drugs.
引用
收藏
页码：5641 / 5656
页数：16
相关论文
共 61 条
  • [1] The potential therapeutic effects of Trifolium alexandrinum extract, hesperetin and quercetin against diabetic nephropathy via attenuation of oxidative stress, inflammation, GSK-3β and apoptosis in male rats
    Abdou, Heba Mohamed
    Abd Elkader, Heba-Tallah Abd Elrahim
    [J]. CHEMICO-BIOLOGICAL INTERACTIONS, 2022, 352
  • [2] Inhibition of liver mitochondrial membrane permeability transition pore opening by quercetin and vitamin E in streptozotocin-induced diabetic rats
    Adeoye, Akinwunmi O.
    Ojowu, John
    Daniel, Oluwatoyin O.
    Olorunsogo, Olufunso O.
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 504 (02) : 460 - 469
  • [3] Hepatic Steatosis Alleviated by a Novel Metformin and Quercetin Combination Activating Autophagy Through the cAMP/AMPK/SIRT1 Pathway
    Afshari, Havva
    Noori, Shokoofe
    Zarghi, Afshin
    [J]. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2023, 22 (01):
  • [4] Quercetin can reduce insulin resistance without decreasing adipose tissue and skeletal muscle fat accumulation
    Arias, N.
    Macarulla, M. T.
    Aguirre, L.
    Martinez-Castano, M. G.
    Portillo, M. P.
    [J]. GENES AND NUTRITION, 2014, 9 (01)
  • [5] Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: A mechanistic study
    Arya, Aditya
    Al-Obaidi, Mazen M. Jamil
    Shahid, Nayiar
    Bin Noordin, Mohamed Ibrahim
    Looi, Chung Yeng
    Wong, Won Fen
    Khaing, Si Lay
    Mustafa, Mohd Rais
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2014, 71 : 183 - 196
  • [6] Quercetin in Food: Possible Mechanisms of Its Effect on Memory
    Babaei, Fatemeh
    Mirzababaei, Mohammadreza
    Nassiri-Asl, Marjan
    [J]. JOURNAL OF FOOD SCIENCE, 2018, 83 (09) : 2280 - 2287
  • [7] Quercetin and metformin synergistically reverse endothelial dysfunction in the isolated aorta of streptozotocin-nicotinamide- induced diabetic rats
    Chellian, Jestin
    Mak, Kit-Kay
    Chellappan, Dinesh Kumar
    Krishnappa, Purushotham
    Pichika, Mallikarjuna Rao
    [J]. SCIENTIFIC REPORTS, 2022, 12 (01)
  • [8] Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans
    Dabeek, Wijdan M.
    Marra, Melissa Ventura
    [J]. NUTRIENTS, 2019, 11 (10)
  • [9] Quercetin and Quercetin-Rich Red Onion Extract Alter Pgc-1α Promoter Methylation and Splice Variant Expression
    Devarshi, Prasad P.
    Jones, Aarin D.
    Taylor, Erin M.
    Stefanska, Barbara
    Henagan, Tara M.
    [J]. PPAR RESEARCH, 2017, 2017
  • [10] Rutin and quercetin enhance glucose uptake in L6 myotubes under oxidative stress induced by tertiary butyl hydrogen peroxide
    Dhanya, R.
    Arun, K. B.
    Syama, H. P.
    Nisha, P.
    Sundaresan, A.
    Kumar, T. R. Santhosh
    Jayamurthy, P.
    [J]. FOOD CHEMISTRY, 2014, 158 : 546 - 554
1234567