DNA Mechanics: From Single Stranded to Self-Assembled

被引：5
作者：
Yang, Linfeng [1 ,2 ]
Li, Qian [1 ,2 ]
Ge, Zhilei [1 ,2 ]
Fan, Chunhai [1 ,2 ]
Huang, Wenmao [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Zhangjiang Inst Adv Study, Sch Chem & Chem Engn, New Cornerstone Sci Lab,Frontiers Sci Ctr Transfor, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, Natl Ctr Translat Med, Shanghai 200240, Peoples R China
来源：
NANO LETTERS | 2024年 / 24卷 / 38期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Mechanics; DNA; Single molecule; Self-assembledDNA; DNA origami; MOLECULE FORCE SPECTROSCOPY; MAGNETIC TWEEZERS; ORIGAMI; TORQUE; STABILITY; TENSION;
D O I：
10.1021/acs.nanolett.4c03323
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
DNA encodes genetic information and forms various structural conformations with distinct physical, chemical, and biological properties. Over the past 30 years, advancements in force manipulation technology have enabled the precise manipulation of DNA at nanometer and piconewton resolutions. This mini-review discusses these force manipulation techniques for exploring the mechanical properties of DNA at the single-molecule level. We summarize the distinct mechanical features of different DNA forms while considering the impact of the force geometry. We highlight the role of DNA mechanics in origami structures that serve as self-assembled building blocks or mechanically responsive/active nanomachines. Accordingly, we emphasize how DNA mechanics are integral to the functionality of origami structures for achieving mechanical capabilities. Finally, we provide an outlook on the intrinsic mechanical properties of DNA, from single stranded to self-assembled higher-dimensional structures. This understanding is expected to inspire new design strategies in DNA mechanics, paving the way for innovative applications and technologies.
引用
收藏
页码：11768 / 11778
页数：11
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