Current and Emerging Treatment Paradigms in Colorectal Cancer: Integrating Hallmarks of Cancer

被引：4

作者：

de Torres, Clara Salva ^{[1
]}

Baraibar, Iosune ^{[2
]}

Gonzalez, Nadia Saoudi ^{[2
]}

Ros, Javier ^{[2
]}

Salva, Francesc ^{[2
]}

Rodriguez-Castells, Marta ^{[2
]}

Alcaraz, Adriana ^{[3
]}

Garcia, Ariadna ^{[3
]}

Tabernero, Josep ^{[2
]}

Elez, Elena ^{[2
]}

机构：

[1] Vall Dhebron Univ Hosp, E-08035 Barcelona, Spain

[2] Vall Dhebron Univ Hosp, Vall Dhebron Inst Oncol VHIO, Med Oncol Dept, E-08035 Barcelona, Spain

[3] Vall Dhebron Inst Oncol VHIO, E-08035 Barcelona, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 13期

关键词：

colorectal cancer; hallmarks of cancer; drug development; cancer biology; targeted therapies; immune checkpoint inhibitors; DOUBLE-BLIND; OPEN-LABEL; PHASE; 1B; PLUS; COMBINATION; MULTICENTER; BEVACIZUMAB; CETUXIMAB; BRAF; INHIBITION;

D O I：

10.3390/ijms25136967

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The treatment of unresectable metastatic colorectal cancer has evolved over the last two decades, as knowledge of cancer biology has broadened and new targets have emerged. 'The Hallmarks of Cancer' illustrate the crucial capabilities acquired by cells to become malignant and represent the evolution of knowledge of tumor biology. This review integrates these novel targets and therapies into selected hallmarks: sustaining proliferative signaling, inducing vasculature, avoiding immune destruction, genome instability and mutation, reprogramming cellular metabolism, and resisting cell death. The different strategies and combinations under study are based on treatments with anti-EGFR, anti-VEGF, and anti-HER2 agents, KRAS G12C inhibitors, BRAF and MEK inhibitors, and immune checkpoint inhibitors. However, new approaches are emerging, including vaccines, WEE1 inhibitors, and PARP inhibitors, among others. The further deciphering of cancer biology will unravel new targets, develop novel therapies, and improve patients' outcomes.

引用

页数：18

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