Comparison of early wound healing using modified papilla preservation technique between enamel matrix derivative and recombinant human fibroblast growth factor

被引：1

作者：

Nakayama, Yohei ^{[1
,2
]}

Tabe, Shinichi ^{[1
]}

Igarashi, Kazuma ^{[1
]}

Moriya, Satoshi ^{[1
]}

Katsumata, Tsuyoshi ^{[1
]}

Kobayashi, Ryo ^{[1
]}

Nakagawa, Shuta ^{[1
]}

Nishino, Tomoko ^{[1
]}

Fukuoka, Namiko ^{[1
]}

Hosono, Kota ^{[1
]}

Yamasaki, Mai ^{[1
]}

Yamazaki, Yosuke ^{[1
]}

Ogihara-Takeda, Moe ^{[1
]}

Ito, Shoichi ^{[1
]}

Saito, Yumi ^{[1
]}

Yamaguchi, Arisa ^{[1
]}

Tsuruya, Yuto ^{[1
]}

Yamazaki-Takai, Mizuho ^{[1
]}

Yoshino, Shoichi ^{[1
]}

Takai, Hideki ^{[1
,2
]}

Ogata, Yorimasa ^{[1
,2
]}

机构：

[1] Nihon Univ, Sch Dent Matsudo, Dept Periodontol, 2-870-1 Sakaecho Nishi, Matsudo, Chiba 2718587, Japan

[2] Nihon Univ, Sch Dent Matsudo, Res Inst Oral Sci, 2-870-1 Sakaecho Nishi, Matsudo, Chiba 2718587, Japan

来源：

JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE | 2024年 / 54卷 / 04期

基金：

日本学术振兴会;

关键词：

Fibroblast growth factor 2; Inflammation; Wound healing; INVASIVE SURGICAL TECHNIQUE; REGENERATIVE TREATMENT; TISSUE REGENERATION; INTRABONY DEFECTS; FLAP; PROLIFERATION; MANAGEMENT; MOLECULES; PROTEINS; ADHESION;

D O I：

10.5051/jpis.2303080154

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Purpose: Enamel matrix derivative (EMD) has demonstrated beneficial effects on wound healing following surgery. However, the effects of recombinant human fibroblast growth factor 2 (rhFGF-2) in periodontal regeneration therapy have not been extensively studied. This retrospective study was conducted to compare the wound healing outcomes of the modified papilla preservation technique (mPPT) between EMD and rhFGF-2 therapies. Methods: A total of 79 sites were evaluated for early wound healing using the modified early wound healing index (mEHI), which included 6 items: incision, fibrin clotting, step, redness, swelling, and dehiscence. A numeric analog scale, along with postoperative images of the 6 mEHI items, was established and used for the evaluations. The inter-rater reliability of the mEHI was assessed via intraclass correlation coefficients (ICCs). After adjusting for factors influencing the mPPT, the differences in mEHI scores between the EMD and rhFGF-2 groups were statistically analyzed. Additionally, radiographic bone fill (RBF) was evaluated 6 months after surgery. Results: The ICC of the mEHI was 0.575. The mEHI, redness score, and dehiscence scores were significantly higher in the rhFGF-2 group (n=33) than in the EMD group (n=46). Similar results were observed in the subgroup of patients aged 50 years or older, but not in those younger than 50 years. In the subgroup with non-contained bone defects, related results were noted, but not in the subgroup with contained bone defects. However, early wound healing did not correlate with RBF at 6 months after surgery. Conclusions: Within the limitations of this study, the findings suggest that early wound healing following the use of mPPT with rhFGF-2 is somewhat superior to that observed after mPPT with EMD. However, mEHI should be improved for use as a predictive tool for early wound healing and to reflect clinical outcomes after surgery.

引用

页码：236 / 252

页数：17

共 40 条

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