Progression of mesenchymal stem cell regulation on imbalanced microenvironment after spinal cord injury

被引：1
作者：
Liu, Yifan [1 ,2 ]
Zhao, Chenxi [1 ]
Zhang, Rong [1 ]
Pang, Yilin [1 ,3 ]
Li, Linquan [1 ]
Feng, Shiqing [1 ,2 ,3 ]
机构：
[1] Shandong Univ, Ctr Orthopaed, Cheeloo Coll Med, Qilu Hosp,Dept Orthopaed,Adv Med Res Inst, 107 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Ctr Orthopaed, Hosp 2, Inst Med Sci,Cheeloo Coll Med, Jinan 250033, Shandong, Peoples R China
[3] Tianjin Med Univ, Dept Orthoped, Int Sci & Technol Cooperat Base Spinal Cord Injury, Tianjin Key Lab Spine & Spinal Cord Injury,Gen Ho, 154 Anshan Rd, Tianjin 300052, Peoples R China
来源：
STEM CELL RESEARCH & THERAPY | 2024年 / 15卷 / 01期
关键词：
Spinal cord injury; Mesenchymal stem cells; Microenvironment imbalance; Paracrine; HUMAN ADIPOSE-TISSUE; CHONDROITIN SULFATE PROTEOGLYCAN; IMPROVES FUNCTIONAL RECOVERY; BONE-MARROW; STROMAL CELLS; INFLAMMATORY CYTOKINES; PATTERN-RECOGNITION; SCAR FORMATION; RAT MODEL; TRANSPLANTATION;
D O I：
10.1186/s13287-024-03914-x
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Spinal cord injury (SCI) results in significant neural damage and inhibition of axonal regeneration due to an imbalanced microenvironment. Extensive evidence supports the efficacy of mesenchymal stem cell (MSC) transplantation as a therapeutic approach for SCI. This review aims to present an overview of MSC regulation on the imbalanced microenvironment following SCI, specifically focusing on inflammation, neurotrophy and axonal regeneration. The application, limitations and future prospects of MSC transplantation are discussed as well. Generally, a comprehensive perspective is provided for the clinical translation of MSC transplantation for SCI.
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页数：23
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