The role of CBL family ubiquitin ligases in cancer progression and therapeutic strategies

被引：1

作者：

Ren, Jiaqi ^{[1
,2
]}

Lv, Linlin ^{[1
]}

Tao, Xufeng ^{[1
]}

Zhai, Xiaohan ^{[1
]}

Chen, Xuyang ^{[1
]}

Yu, Hao ^{[1
,2
]}

Zhao, Xinya ^{[1
,2
]}

Kong, Xin ^{[1
,2
]}

Yu, Zhan ^{[1
]}

Dong, Deshi ^{[1
]}

Liu, Jing ^{[3
]}

机构：

[1] Dalian Med Univ, Dept Pharm, Affiliated Hosp 1, Dalian, Peoples R China

[2] Dalian Med Univ, Sch Pharm, Dalian, Peoples R China

[3] Dalian Med Univ, Affiliated Hosp 1, Stem Cell Clin Res Ctr, Natl Joint Engn Lab, Dalian, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷

关键词：

CBL; cancer; E3 ubiquitin ligase; targeted therapy; immunotherapy; GROWTH-FACTOR RECEPTOR; TRAIL-INDUCED APOPTOSIS; CELL LUNG-CANCER; SMALL-MOLECULE INHIBITOR; C-CBL; GASTRIC-CANCER; PROSTATE-CANCER; TYROSINE KINASE; DOWN-REGULATION; E3; LIGASE;

D O I：

10.3389/fphar.2024.1432545

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The CBL (Casitas B-lineage lymphoma) family, as a class of ubiquitin ligases, can regulate signal transduction and activate receptor tyrosine kinases through various tyrosine kinase-dependent pathways. There are three members of the family: c-CBL, CBL-b, and CBL-c. Numerous studies have demonstrated the important role of CBL in various cellular pathways, particularly those involved in the occurrence and progression of cancer, hematopoietic development, and regulation of T cell receptors. Therefore, the purpose of this review is to comprehensively summarize the function and regulatory role of CBL family proteins in different human tumors, as well as the progress of drug research targeting CBL family, so as to provide a broader clinical measurement strategy for the treatment of tumors.

引用

页数：24

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