Neonatal Azithromycin Exposure and Childhood Growth: Long-Term Follow-Up of a Randomized Controlled Trial

被引：1

作者：

Bountogo, Mamadou ^{[1
]}

Ouermi, Lucienne ^{[1
]}

Dah, Clarisse ^{[1
]}

Sie, Ali ^{[1
]}

Coulibaly, Boubacar ^{[1
]}

Zakane, Alphonse ^{[1
]}

Ouedraogo, Thierry ^{[1
]}

Ouattara, Mamadou ^{[1
]}

Lebas, Elodie ^{[2
]}

Fetterman, Ian ^{[2
]}

Kimfuema, Aimee ^{[2
]}

Doan, Thuy ^{[2
,3
]}

Lietman, Thomas M. ^{[2
,3
,4
]}

Oldenburg, Catherine E. ^{[2
,3
,4
]}

机构：

[1] Ctr Rech Santa & Nouna, Nouna, Burkina Faso

[2] Univ Calif San Francisco, Francis I Proctor Fdn, San Francisco, CA USA

[3] Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2024年 / 111卷 / 03期

关键词：

MICROBIOTA; MORTALITY;

D O I：

10.4269/ajtmh.24-0016

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Single-dose azithromycin is being considered by the WHO as an intervention for prevention of child mortality. However, concerns have emerged related to longer term unintended consequences of early life antibiotic use, particularly among infants. We conducted a long-term follow-up in a random sample of children who had been enrolled in a trial of neonatal azithromycin versus placebo for prevention of mortality to assess whether neonatal azithromycin exposure led to differences in child growth up to 4 years of age. We found no evidence of a difference in any anthropometric outcome among children who had received a single oral dose of azithromycin compared with placebo during the neonatal period. These results do not support long-term growth-promoting or deleterious effects of early life azithromycin exposure.

引用

页码：698 / 702

页数：5

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