The role of polyphenols in modulating mitophagy: Implications for therapeutic interventions

被引：4

作者：

Lin, Xinyu ^{[1
]}

Liu, Wenkai ^{[2
]}

Hu, Xizhuo ^{[1
]}

Liu, Zhiqiang ^{[2
]}

Wang, Fang ^{[3
]}

Wang, Jinlian ^{[4
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China

[2] Deyang Sixth Peoples Hosp, Deyang 618000, Peoples R China

[3] Chengdu First Peoples Hosp, Sichuan, Peoples R China

[4] Tradit Chinese Med Hosp Meishan, Meishan 620010, Peoples R China

来源：

PHARMACOLOGICAL RESEARCH | 2024年 / 207卷

关键词：

Polyphenols; Mitophagy; Natural products; Signaling pathways; Therapeutic interventions; MITOCHONDRIAL BIOGENESIS; EPITHELIAL-CELLS; MUSCLE ATROPHY; RESVERATROL; AUTOPHAGY; UROLITHIN; CURCUMIN; HEALTH; DEATH; PHARMACOKINETICS;

D O I：

10.1016/j.phrs.2024.107324

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review rigorously assesses the burgeoning research into the role of polyphenols in modulating mitophagy, an essential cellular mechanism for the targeted removal of impaired mitochondria. These natural compounds, known for their low toxicity, are underscored for their potential in therapeutic strategies against a diverse array of diseases, such as neurodegenerative, cardiovascular, and musculoskeletal disorders. The analysis penetrates deeply into the molecular mechanisms whereby polyphenols promote mitophagy, particularly by influencing crucial signaling pathways and transcriptional regulators, including the phosphatase and tensin homolog (PTEN) induced putative kinase 1 (PINK1)/parkin and forkhead box O3 (FOXO3a) pathways. Noteworthy discoveries include the neuroprotective properties of resveratrol and curcumin, which affect both autophagic pathways and mitochondrial dynamics, and the pioneering integration of polyphenols with other natural substances to amplify therapeutic effectiveness. Furthermore, the review confronts the issue of polyphenol bioavailability and emphasizes the imperative for clinical trials to corroborate their therapeutic viability. By delivering an exhaustive synthesis of contemporary insights and recent advancements in polyphenol and mitophagy research, this review endeavors to catalyze additional research and foster the creation of innovative therapeutic modalities that exploit the distinctive attributes of polyphenols to manage and prevent disease.

引用

页数：16