Health-related quality of life with comprehensive geriatric assessment guided care versus usual care in older adults with cancer: A systematic review and meta-analysis of randomized trials

被引：1
作者：
Ng, Zhi Xuan [1 ]
Handa, Pooja [1 ]
Zheng, Huili [2 ]
Chen, Matthew Zhixuan [3 ,4 ]
Soon, Yu Yang [1 ,4 ,5 ]
Blinman, Prunella [6 ]
Stockler, Martin [5 ,6 ,7 ]
Ho, Francis [1 ,4 ]
机构：
[1] Natl Univ Canc Inst, Dept Radiat Oncol, Singapore, Singapore
[2] Khoo Teck Puat Hosp, Clin Res Unit, Singapore, Singapore
[3] Natl Univ Singapore Hosp, Dept Med, Div Geriatr Med, Singapore, Singapore
[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore
[5] Univ Sydney, NHMRC Clin Trials Ctr, Sydney, NSW, Australia
[6] Concord Repatriat Gen Hosp, Dept Med Oncol, Sydney, NSW, Australia
[7] Chris OBrien Lifehouse, Dept Med Oncol, Sydney, NSW, Australia
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2024年 / 201卷
基金：
英国医学研究理事会;
关键词：
Geriatric Oncology; Comprehensive Geriatric Assessment; Health -related quality of life; Randomized trials; MANAGEMENT;
D O I：
10.1016/j.critrevonc.2024.104442
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: To evaluate if comprehensive geriatric assessment (CGA)-guided care improves health-related quality of life (HRQL) in older adults with cancer compared to usual care. Methods: Relevant randomized controlled trials (RCTs) were identified through biomedical databases. Metaanalyses using DerSimonian-Laird model summarized the difference in the mean change of HRQL scores from baseline across various time points, with evidence certainty assessed by the GRADE tool. Logistic regression via generalized estimating equations analyzed predictors of HRQL improvement. Results: Potential improvement in the global HRQL score by CGA-guided care at 3 months (Cohen's d 0.27, 95 % CI - 0.03-0.58, moderate certainty), could not be excluded. Larger RCTs or those mandating CGA before initiating anti-cancer treatment were predictors of improved HRQL. Conclusion: The effects of CGA-guided care on HRQL were variable. Larger RCTs and those mandating pretreatment CGA tended to report improved HRQL.
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页数：6
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共 23 条
  • [1] Effectiveness of geriatric assessment and management in older cancer patients: a systematic review and meta-analysis
    Anwar, Mohammed Rashidul
    Yeretzian, Shant Torkom
    Ayala, Ana Patricia
    Matosyan, Emma
    Breunis, Henriette
    Bote, Kathyrin
    Puts, Martine
    Habib, Mohammed Hassan
    Li, Qixuan
    Sahakyan, Yeva
    Alibhai, Shabbir M. H.
    Abrahamyan, Lusine
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2023, 115 (12): : 1483 - 1496
  • [2] Screening older cancer patients: first evaluation of the G-8 geriatric screening tool
    Bellera, C. A.
    Rainfray, M.
    Mathoulin-Pelissier, S.
    Mertens, C.
    Delva, F.
    Fonck, M.
    Soubeyran, P. L.
    [J]. ANNALS OF ONCOLOGY, 2012, 23 (08) : 2166 - 2172
  • [3] Evaluating medical tests: introducing the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy
    Bossuyt, Patrick M.
    Deeks, Jonathan J.
    Leeflang, Mariska M.
    Takwoingi, Yemisi
    Flemyng, Ella
    [J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2023, (07):
  • [4] Cohen J., 1988, Statistical power analysis for the behavioral sciences, V2nd
  • [5] Use of a Comprehensive Geriatric Assessment for the Management of Elderly Patients With Advanced Non-Small-Cell Lung Cancer: The Phase III Randomized ESOGIA-GFPC-GECP 08-02 Study
    Corre, Romain
    Greillier, Laurent
    Le Caer, Herve
    Audigier-Valette, Clarisse
    Baize, Nathalie
    Berard, Henri
    Falchero, Lionel
    Monnet, Isabelle
    Dansin, Eric
    Vergnenegre, Alain
    Marcq, Marie
    Decroisette, Chantal
    Auliac, Jean-Bernard
    Bota, Suzanna
    Lamy, Regine
    Massuti, Bartomeu
    Dujon, Cecile
    Perol, Maurice
    Daures, Jean-Pierre
    Descourt, Renaud
    Lena, Herve
    Plassot, Carine
    Chouaid, Christos
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (13) : 1476 - +
  • [6] Effects of a Geriatric Assessment Intervention on Patient-Reported Symptomatic Toxicity in Older Adults With Advanced Cancer
    Culakova, Eva
    Mohile, Supriya G.
    Peppone, Luke
    Ramsdale, Erika
    Mohamed, Mostafa
    Xu, Huiwen
    Wells, Megan
    Tylock, Rachael
    Java, Jim
    Loh, Kah Poh
    Magnuson, Allison
    Jamieson, Leah
    Vogel, Victor
    Duberstein, Paul R.
    Chapman, Benjamin P.
    Dale, William
    Flannery, Marie Anne
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (04) : 835 - +
  • [7] The effect of comprehensive geriatric assessment on care received, treatment completion, toxicity, cancer-related and geriatric assessment outcomes, and quality of life for older adults receiving systemic anti-cancer treatment: A systematic review
    Disalvo, Domenica
    Moth, Erin
    Soo, Wee Kheng
    V. Garcia, Maja
    Blinman, Prunella
    Steer, Christopher
    Amgarth-Duff, Ingrid
    Power, Jack
    Phillips, Jane
    Agar, Meera
    [J]. JOURNAL OF GERIATRIC ONCOLOGY, 2023, 14 (08)
  • [8] Randomized controlled trial of geriatric consultation versus standard care in older adults with hematologic malignancies
    DuMontier, Clark
    Uno, Hajime
    Hshieh, Tammy
    Zhou, Guohai
    Chen, Richard
    Magnavita, Emily S.
    Mozessohn, Lee
    Javedan, Houman
    Stone, Richard M.
    Soiffer, Robert J.
    Driver, Jane A.
    Abel, Gregory A.
    [J]. HAEMATOLOGICA, 2022, 107 (05) : 1172 - 1180
  • [9] GRADE:: an emerging consensus on rating quality of evidence and strength of recommendations
    Guyatt, Gordon H.
    Oxman, Andrew D.
    Vist, Gunn E.
    Kunz, Regina
    Falck-Ytter, Yngve
    Alonso-Coello, Pablo
    Schuenemann, Holger J.
    [J]. BRITISH MEDICAL JOURNAL, 2008, 336 (7650): : 924 - 926
  • [10] The effect of a geriatric evaluation on treatment decisions and outcome for older cancer patients - A systematic review
    Hamaker, Marije E.
    te Molder, Marthe
    Thielen, Noortje
    van Munster, Barbara C.
    Schiphorst, Anandi H.
    van Huis, Lieke H.
    [J]. JOURNAL OF GERIATRIC ONCOLOGY, 2018, 9 (05) : 430 - 440
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