Levofloxacin prophylaxis in pediatric oncology and hematopoietic stem cell transplantation: a literature review

被引：2

作者：

Koo, Jane ^{[1
,2
]}

Hord, Jeffrey ^{[3
]}

Gilliam, Craig ^{[4
]}

Rae, Mary Lynn ^{[5
]}

Staubach, Katherine ^{[6
]}

Nowacki, Katherine ^{[6
]}

Lyren, Anne ^{[7
,8
]}

Coffey, Maitreya ^{[9
]}

Dandoy, Christopher E. ^{[1
,2
,6
]}

机构：

[1] Cincinnati Childrens Med Ctr, Div Bone Marrow Transplantat & Immune Deficiency, Cincinnati, OH USA

[2] Univ Cincinnati, Coll Med, Cincinnati, OH USA

[3] Akron Childrens Hosp, Showers Family Ctr Childhood Canc & Blood Disorde, Akron, OH USA

[4] St Jude Childrens Res Hosp, Dept Infect Prevent & Control, Memphis, TN USA

[5] Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL USA

[6] Cincinnati Childrens Med Ctr, James M Anderson Ctr Hlth Syst Excellence, Cincinnati, OH USA

[7] Case Western Reserve Univ, Univ Hosp Rainbow Babies, Cleveland, OH USA

[8] Childrens Hosp Cleveland, Cleveland, OH USA

[9] Hosp Sick Children, Toronto, ON, Canada

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2024年 / 41卷 / 06期

关键词：

Blood stream infection; levofloxacin; pediatric bone marrow transplant; pediatric cancer; prophylaxis; BLOOD-STREAM INFECTIONS; VANCOMYCIN-RESISTANT ENTEROCOCCI; ACUTE LYMPHOBLASTIC-LEUKEMIA; CARE-ASSOCIATED INFECTIONS; ANTIBACTERIAL PROPHYLAXIS; ANTIBIOTIC-PROPHYLAXIS; RISK-FACTORS; FEBRILE NEUTROPENIA; CLINICAL IMPACT; CANCER;

D O I：

10.1080/08880018.2024.2353888

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bloodstream infections (BSI) are one of the leading causes of morbidity and mortality in children and young adults receiving chemotherapy for malignancy or undergoing hematopoietic stem cell transplantation (HSCT). Antibiotic prophylaxis is commonly used to decrease the risk of BSI; however, antibiotics carry an inherent risk of complications. The aim of this manuscript is to review levofloxacin prophylaxis in pediatric oncology patients and HSCT recipients. We reviewed published literature on levofloxacin prophylaxis to prevent BSI in pediatric oncology patients and HSCT recipients. Nine manuscripts were identified. The use of levofloxacin is indicated in neutropenic children and young adults receiving intensive chemotherapy for leukemia or undergoing HSCT. These results support the efficacy of levofloxacin in pediatric patients with leukemia receiving intensive chemotherapy and should be considered in pediatric patients undergoing HSCT prior to engraftment.

引用

页码：432 / 448

页数：17

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