Electroreductive Cross-Coupling between Aromatic Aldehydes and Chlorosilanes Enabling the Synthesis of α-Silyl Alcohols

被引：2

作者：

Han, Fen ^{[1
]}

Su, Qian ^{[1
]}

Li, Yu ^{[1
]}

Hao, Jianjun ^{[1
]}

Peng, Yulin ^{[1
]}

Zhang, Zhengbing ^{[1
]}

Jing, Linhai ^{[1
]}

Han, Pan ^{[1
]}

机构：

[1] China West Normal Univ, Coll Chem & Chem Engn, Chem Synth & Pollut Control Key Lab Sichuan Prov, Nanchong 637002, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 33期

基金：

中国国家自然科学基金;

关键词：

BROOK REARRANGEMENT; NUCLEOPHILIC SILICON; CARBONYL-COMPOUNDS; ACYL SILANES; GENERATION; REDUCTION; ACYLSILANES; CHEMISTRY; CATALYST;

D O I：

10.1021/acs.orglett.4c02607

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Silyl alcohols are powerful structural motifs for pharmaceutical chemistry, materials chemistry, and organic synthesis. The limitations of current synthetic techniques encompass a requirement for difficult-to-obtain silyl precursors, noble-metal catalysts, and narrow substrate scopes. Here, we developed a general synthetic method for alpha-silyl alcohols through electroreductive cross-coupling of aldehydes and chlorosilane. This method features easily available reagents, mild conditions, and a wide substrate scope. The establishment of this protocol will provide an alternative for access to alpha-silyl alcohols.

引用

页码：7037 / 7042

页数：6

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