Renal Dysfunction in a Patient With Crohn's Disease During Ustekinumab Treatment: A Case Report and Review of the Literature

被引：0
作者：
Wei, Yuge [1 ]
Ruan, Gechong [2 ]
Qin, Yan [3 ]
Bai, Xiaoyin [2 ]
Yang, Hong [2 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Med Doctor Program, Beijing, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gastroenterol, Beijing, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Nephrol, Beijing, Peoples R China
来源：
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL | 2024年 / 101卷
关键词：
Crohn's disease; Renal insufficiency; Ustekinumab; MAINTENANCE THERAPY; INDUCTION; EFFICACY; SAFETY;
D O I：
10.1016/j.curtheres.2024.100753
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Ustekinumab is a first-line drug for Crohn's disease. However, little is known about its potential adverse effects on renal function. We present the case of a 42-year-old man with Crohn's disease who developed chronic renal dysfunction during ustekinumab treatment, which resolved after discontinuing ustekinumab. The findings underscore the importance of close monitoring of renal function in patients receiving ustekinumab, particularly those with preexisting kidney disease or risk factors for renal dysfunction. (c) 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC license ( http://creativecommons.org/licenses/by-nc/4.0/ )
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相关论文
共 14 条
[1]   Biologics and Targeted Synthetic Drugs Can Induce Immune-Mediated Glomerular Disorders in Patients with Rheumatic Diseases: An Updated Systematic Literature Review [J].
Chessa, Elisabetta ;
Piga, Matteo ;
Floris, Alberto ;
Congia, Mattia ;
Cangemi, Ignazio ;
Mathieu, Alessandro ;
Cauli, Alberto .
BIODRUGS, 2021, 35 (02) :175-186
[2]   Efficacy and safety of ustekinumab in a patient with chronic renal failure on hemodialysis [J].
de Unamuno Bustos, Blanca ;
Ballester Sanchez, Rosa ;
Oliver Martinez, Vicente ;
Sanchez Carazo, Jose Luis .
INTERNATIONAL JOURNAL OF DERMATOLOGY, 2014, 53 (04) :E299-E301
[3]   Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease [J].
Feagan, B. G. ;
Sandborn, W. J. ;
Gasink, C. ;
Jacobstein, D. ;
Lang, Y. ;
Friedman, J. R. ;
Blank, M. A. ;
Johanns, J. ;
Gao, L. -L. ;
Miao, Y. ;
Adedokun, O. J. ;
Sands, B. E. ;
Hanauer, S. B. ;
Vermeire, S. ;
Targan, S. ;
Ghosh, S. ;
de Villiers, W. J. ;
Colombel, J. -F. ;
Tulassay, Z. ;
Seidler, U. ;
Salzberg, B. A. ;
Desreumaux, P. ;
Lee, S. D. ;
Loftus, E. V., Jr. ;
Dieleman, L. A. ;
Katz, S. ;
Rutgeerts, P. .
NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (20) :1946-1960
[4]  
Fernando S, 2023, J CROHNS COLITIS, V17, pI307
[5]   EXTRA-INTESTINAL COMPLICATIONS OF CROHNS-DISEASE AND ULCERATIVE-COLITIS - STUDY OF 700 PATIENTS [J].
GREENSTEIN, AJ ;
JANOWITZ, HD ;
SACHAR, DB .
MEDICINE, 1976, 55 (05) :401-412
[6]   Crescentic IgA nephropathy after administration of human monoclonal interleukin-12/23p40 antibody in a patient with Crohn's disease: a case report [J].
Kanazawa, Nobuhiro ;
Wada, Yukihiro ;
Akiyama, Minako ;
Shikida, Yasuto ;
Sugiyama, Motonori ;
Abe, Maki ;
Iyoda, Masayuki ;
Honda, Kazuho ;
Shibata, Takanori .
CEN CASE REPORTS, 2020, 9 (03) :204-209
[7]   Renal and Urological Disorders Associated With Inflammatory Bowel Disease [J].
Kumar, Shankar ;
Pollok, Richard ;
Goldsmith, David .
INFLAMMATORY BOWEL DISEASES, 2023, 29 (08) :1306-1316
[8]   A METHOD FOR ESTIMATING THE PROBABILITY OF ADVERSE DRUG-REACTIONS [J].
NARANJO, CA ;
BUSTO, U ;
SELLERS, EM ;
SANDOR, P ;
RUIZ, I ;
ROBERTS, EA ;
JANECEK, E ;
DOMECQ, C ;
GREENBLATT, DJ .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1981, 30 (02) :239-245
[9]  
Fernández MP, 2019, NEFROLOGIA, V39, P100, DOI [10.1016/j.nefroe.2018.06.016, 10.1016/j.nefro.2018.06.003]
[10]   A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease [J].
Sandborn, William J. ;
Feagan, Brian G. ;
Fedorak, Richard N. ;
Scherl, Ellen ;
Fleisher, Mark R. ;
Katz, Seymour ;
Johanns, Jewel ;
Blank, Marion ;
Rutgeerts, Paul .
GASTROENTEROLOGY, 2008, 135 (04) :1130-1141
12