A new isoprenyl-phenol-type meroterpenoid from mangrove endophytic fungus Aspergillus sp. GXNU-Y65

被引：0

作者：

Wang, Fan-Fan ^{[1
]}

Huang, Guo-Bao ^{[1
]}

Lu, Cai-Hong ^{[1
]}

Chen, Li-Jun ^{[1
]}

Chen, Hui-Zhen ^{[1
]}

Luo, Meng-Qin ^{[1
]}

Tao, Ping-Fang ^{[1
]}

Tan, Ming-Xiong ^{[1
]}

Qin, Feng ^{[1
]}

机构：

[1] Yulin Normal Univ, Coll Chem & Food Sci, Guangxi Key Lab Agr Resources Chem & Biotechnol, Yulin, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2024年

基金：

中国国家自然科学基金;

关键词：

Aspergillus sp; mangrove endophytic fungus; asperphenol A; cytotoxic activity;

D O I：

10.1080/14786419.2024.2390614

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Asperphenol A (1), a new isoprenyl-phenol-type meroterpenoid, was isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y65 together with five known compounds (2-6). All structures were assigned using extensive NMR spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds 1-6 were evaluated for their cytotoxic activity against A549 and T24 human cancer cell lines. Among them, compounds 1 and 5 exhibited moderate inhibitory activities against T24 cancer cell lines with the IC50 values of 26.71 and 43.50 mu M, respectively.

引用

页数：5

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