Regulation of fatty acid synthase on tumor and progress in the development of related therapies

被引：4
作者：
Bai, Rilan [1 ]
Cui, Jiuwei [1 ]
机构：
[1] First Hosp Jilin Univ, Canc Ctr, Changchun 130021, Jilin, Peoples R China
来源：
CHINESE MEDICAL JOURNAL | 2024年 / 137卷 / 16期
关键词：
Neoplasm; Fatty acid synthase; Fatty acid synthase inhibitor; Immune regulation; PI3K/AKT SIGNALING PATHWAY; COLORECTAL-CANCER CELLS; MITOCHONDRIAL FUSION; LIPID-SYNTHESIS; OVARIAN-CANCER; INHIBITION; METASTASIS; METABOLISM; RESISTANCE; APOPTOSIS;
D O I：
10.1097/CM9.0000000000002880
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Fatty acid synthase (FASN) is an essential molecule in lipid metabolic pathways, which are crucial for cancer-related studies. Recent studies have focused on a comprehensive understanding of the novel and important regulatory effects of FASN on malignant biological behavior and immune-cell infiltration, which are closely related to tumor occurrence and development, immune escape, and immune response. FASN-targeting antitumor treatment strategies are being developed. Therefore, in this review, we focused on the effects of FASN on tumor and immune-cell infiltration and reviewed the progress of related anti-tumor therapy development.
引用
收藏
页码：1894 / 1902
页数：9
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