Noninfective Endocarditis in a Young Patient with Systemic Lupus Erythematosus

Noninfective endocarditis, particularly in association with systemic autoimmune diseases like systemic lupus erythematosus (SLE), presents a diagnostic challenge due to its nonspecific symptoms and the potential for severe cardiac complications. We describe a case of a 16-year-old female diagnosed with SLE who presented with fever, malaise, and a new heart murmur. Subsequent investigations revealed vegetations on the mitral valve consistent with noninfective endocarditis without any evidence of infectious etiology. This case underscores the importance of considering noninfective endocarditis in the differential diagnosis for patients with systemic autoimmune disorders presenting with fever and cardiac symptoms. Early recognition and management are crucial to prevent serious outcomes. (International Journal of Biomedicine. 2024;14(2):338-340.)